New Publications From Collins Lab!


Increased Energy Expenditure and Protection From Diet-Induced Obesity in Mice Lacking the cGMP-Specific Phosphodiesterase PDE9.

Ceddia RP, Liu D, Shi F, Crowder MK, Mishra S, Kass DA, Collins S.

Diabetes. 2021 Dec;70(12):2823-2836. doi: 10.2337/db21-0100. Epub 2021 Oct 7.

PMID: 34620617


Inhibition of phosphodiesterase type 9 reduces obesity and cardiometabolic syndrome in mice.

Mishra S, Sadagopan N, Dunkerly-Eyring B, Rodriguez S, Sarver DC, Ceddia RP, Murphy SA, Knutsdottir H, Jani VP, Ashok D, Oeing CU, O'Rourke B, Gangoiti JA, Sears DD, Wong GW, Collins S, Kass DA.

J Clin Invest. 2021 Nov 1;131(21):e148798. doi: 10.1172/JCI148798.

PMID: 34618683


Adaptations in Hippo-Yap signaling and myofibroblast fate underlie scar-free ear appendage wound healing in spiny mice.

Brewer CM, Nelson BR, Wakenight P, Collins SJ, Okamura DM, Dong XR, Mahoney WM Jr, McKenna A, Shendure J, Timms A, Millen KJ, Majesky MW.

Dev Cell. 2021 Oct 11;56(19):2722-2740.e6. doi: 10.1016/j.devcel.2021.09.008. Epub 2021 Oct 4.

PMID: 34610329


Diet-dependent natriuretic peptide receptor C expression in adipose tissue is mediated by PPARγ via long-range distal enhancers.

Shi F, Simandi Z, Nagy L, Collins S.

J Biol Chem. 2021 Aug;297(2):100941. doi: 10.1016/j.jbc.2021.100941. Epub 2021 Jul 7.

PMID: 34245781 Free PMC article.


Caloric restriction disrupts the microbiota and colonization resistance.

von Schwartzenberg RJ, Bisanz JE, Lyalina S, Spanogiannopoulos P, Ang QY, Cai J, Dickmann S, Friedrich M, Liu SY, Collins SL, Ingebrigtsen D, Miller S, Turnbaugh JA, Patterson AD, Pollard KS, Mai K, Spranger J, Turnbaugh PJ.

Nature. 2021 Jul;595(7866):272-277. doi: 10.1038/s41586-021-03663-4. Epub 2021 Jun 23.

PMID: 34163067 Clinical Trial.


Physical, Biochemical, and Biologic Properties of Fat Graft Processed via Different Methods.

Fang C, Patel P, Li H, Huang LT, Wan H, Collins S, Connell TL, Xu H.

Plast Reconstr Surg Glob Open. 2020 Aug 18;8(8):e3010. doi: 10.1097/GOX.0000000000003010. eCollection 2020 Aug.

PMID: 32983771 Free PMC article.


Manipulation of Dietary Amino Acids Prevents and Reverses Obesity in Mice Through Multiple Mechanisms That Modulate Energy Homeostasis.

Ruocco C, Ragni M, Rossi F, Carullo P, Ghini V, Piscitelli F, Cutignano A, Manzo E, Ioris RM, Bontems F, Tedesco L, Greco CM, Pino A, Severi I, Liu D, Ceddia RP, Ponzoni L, Tenori L, Rizzetto L, Scholz M, Tuohy K, Bifari F, Di Marzo V, Luchinat C, Carruba MO, Cinti S, Decimo I, Condorelli G, Coppari R, Collins S, Valerio A, Nisoli E.

Diabetes. 2020 Nov;69(11):2324-2339. doi: 10.2337/db20-0489. Epub 2020 Aug 10.

PMID: 32778569 Free PMC article.


HIV-Exposed, Uninfected Infants in Uganda Experience Poorer Growth and Body Composition Trajectories than HIV-Unexposed Infants.

Lane CE, Widen EM, Collins SM, Young SL.

J Acquir Immune Defic Syndr. 2020 Oct 1;85(2):138-147. doi: 10.1097/QAI.0000000000002428.

PMID: 32604132 Free PMC article.


The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation.

Fischer K, Fenzl A, Liu D, Dyar KA, Kleinert M, Brielmeier M, Clemmensen C, Fedl A, Finan B, Gessner A, Jastroch M, Huang J, Keipert S, Klingenspor M, Brüning JC, Kneilling M, Maier FC, Othman AE, Pichler BJ, Pramme-Steinwachs I, Sachs S, Scheideler A, Thaiss WM, Uhlenhaut H, Ussar S, Woods SC, Zorn J, Stemmer K, Collins S, Diaz-Meco M, Moscat J, Tschöp MH, Müller TD.

Nat Commun. 2020 May 8;11(1):2306. doi: 10.1038/s41467-020-16230-8.

PMID: 32385399 Free PMC article.


Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration.

Guilherme A, Yenilmez B, Bedard AH, Henriques F, Liu D, Lee A, Goldstein L, Kelly M, Nicoloro SM, Chen M, Weinstein L, Collins S, Czech MP.

Cell Rep. 2020 May 5;31(5):107598. doi: 10.1016/j.celrep.2020.107598.

PMID: 32375048 Free PMC article.


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