Obesity/Nutrition – Nina Hill
Background
- BMI = Body Weight (kg) + Height (meters) squared
- Overweight = BMI 25.0-29.9
- Obesity:
- Class I 30-34.9
- Class II 35-39.9
- Class IIIA 40-44.9
- Class IIIB 45-49.9
- Class IIIC 50+
Management
- Goals: Target initial weight loss of 5-7% body weight, schedule frequent follow up to assess progress. Request pts send 48 hr food log. Encourage accountability “buddies.” Consider weight loss apps: My Fitness Pal, Lose it
- Diet:
- Calorie restriction > macronutrient composition (e.g., low fat, low carb)
- Mediterranean: high in unsaturated fats, fruit/veg, legumes, grains; moderate dairy & EtOH; less meat (decreased overall mortality and CV mortality; may decrease diabetes incidence independent of weight loss)
- Dot phrases below for pictoral representation of cultural diets adapted to fit Mediterranean guidelines (Asian, African, Latin American)
- DASH: High in fruits/vegetables, moderate dairy, < 25% caloric intake from fat (decreases SBP/DBP)
- Exercise: >30 min, 5-7 days per week, ideally a combo of aerobic + resistance training.
- Exercise alone is not sufficient for weight loss.
- Medications: If BMI ≥30 or BMI ≥27 with ≥1 comorbidity. Significant short term weight loss (~ 5-15 lbs), but weight is typically gained back when stopped
- Referral to medical weight loss: If BMI ≥ 30 or BMI ≥27 with comorbid conditions (fatty liver disease, diabetes mellitus, HTN, OSA)
- Referral to surgical weight loss: If BMI ≥40 or BMI ≥35 with comorbid conditions
Medication |
Mechanism |
Common Side Effects |
Orlistat (Xenical) |
Reduces fat adsorption |
Diarrhea, gas, leakage of oily stools, stomach pain |
Phentermine-topiramate (Qsymia) |
Phentermine: appetite suppression |
Constipation, dizziness, dry mouth, taste changes, tingling of hands and feet, insomnia |
Naltrexone-bupropion (Contrave) |
Naltrexone (partial opioid antagonist; used for alcohol dependence): ?altered satiety perception |
Constipation, diarrhea, dizziness, dry mouth, headache, BP, tachycardia, insomnia, liver damage, nausea/vomiting |
Liraglutide (Saxenda) |
Appetite suppression; quickens satiety |
Nausea, diarrhea, constipation, abdominal pain, headache, tachycardia |
Phentermine (Ionamin) |
Reduces appetite |
Dry mouth, constipation, insomnia, dizziness, nervousness/ restlessness headache, HTN, tachycardia |
Semaglutide (Ozempic/Rybelsus) |
Glucagon-like peptide-1 receptor agonist; reduces appetite |
Nausea, vomiting, diarrhea, abdominal pain, constipation |