Knock-out of Sox6 in renin expressing cells inhibits hypertension induced by renal artery stenosis and kidney damage. Sox6 plays a novel role in renal physiology; modulating renin expression during pathological conditions. These results will aid in the discovery of a novel transcriptional…

Human induced pluripotent stem cells (iPSCs) generated kidney organoids. (A) Protocol scheme showing representative pictures during kidney organoid formation. Scale bars: 500 µm. (B) Characterization of kidney organoids at day 26; CDH1, marker of distal tubes and…

The Renin Angiotensin Aldosterone System (RAAS) plays a key role in regulating blood pressure in humans. Renin controls the rate-limiting step in the conversion of angiotensinogen to angiotensin I. In adults, renin is produced and stored by juxtaglomerular (JG) cells…

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Laboratory Projects and Interests

  • Regulation of renin expression and blood pressure control and kidney development.
  • Sox6 role in renin regulation and hypertension control, specifically in renal artery stenosis induced hypertension.
  • Use of human induced pluripotent stem cells to generate kidney organoids to study Sox6 function in hypertension
  • Use BioVU to examine the association of Sox6 with disease outcomes in humans with hypertension and other cardiovascular diseases.

Funding

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