Brian R. Lindman, MD, MSCI

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Associate Professor of Medicine, Division of Cardiovascular Medicine

Medical Director, Structural Heart and Valve Center

Research Description

My research is centered on calcific aortic stenosis, including several clinical and translational projects related to biomarker discovery, risk prediction, and elucidating pathophysiology to identify adjunctive interventions to improve patient-centered outcomes. Our group uses various imaging techniques and a biobank of specimens to perform biomarker discovery and understand the pathobiology of aortic stenosis and the effects of pressure overload on the left ventricle and pulmonary vasculature. We have a particular interest in how diabetes affects these processes and aim to identify novel targets for adjunctive medical therapy to improve clinical outcomes in patients with aortic stenosis. Novel rehabilitation strategies targeting frailty are also an area of interest.

Brief Description

Dr. Lindman spends most of his time on numerous clinical and translational research projects on calcific aortic stenosis. His group uses sophisticated imaging techniques and a biobank of specimens to elucidate the pathobiology of aortic stenosis and the effects of pressure overload on the left ventricle and pulmonary vasculature. He has a particular interest in how diabetes affects these processes and aims to identify novel targets for adjunctive medical therapy to improve clinical outcomes in patients with aortic stenosis. He is an integral member of his institution’s heart valve team, evaluating patients clinically and performing the transesophageal echocardiograms for transcatheter valve procedures. Dr. Lindman is a member of several writing groups for the American College of Cardiology (ACC), including the Appropriate Use Criteria for Aortic Stenosis and a clinical policy document on advanced valve centers. By participating in these national efforts, he seeks to play a role in shaping new systems of care for patients with valve disease that improve patient-centered outcomes. Dr. Lindman is on the editorial boards for leading cardiovascular journals, including JACC and Circulation, and actively publishes original research manuscripts in these and other journals. He has been the recipient of numerous government, foundation, and industry grants, including an NIH K23 Career Development Award and a Doris Duke Clinical Scientist Development Award. Outside of work, he enjoys spending time with his wife and 3 daughters.

Email
brian.r.lindman@vumc.org

Education

MD - Vanderbilt School of Medicine
MSCI - Washington University School of Medicine

Clinical interest

I am actively involved in our heart valve team, evaluating patients clinically and performing the transesophageal echocardiograms for transcatheter valve procedures. My research is centered on calcific aortic stenosis, including several clinical and translational projects. Our group uses various imaging techniques and a biobank of specimens to perform biomarker discovery and elucidate the pathobiology of aortic stenosis and the effects of pressure overload on the left ventricle and pulmonary vasculature. We have a particular interest in how diabetes affects these processes and aim to identify novel targets for adjunctive medical therapy to improve clinical outcomes in patients with aortic stenosis. Novel rehabilitation strategies targeting frailty are also an area of interest. As a heart valve center, we seek to integrate a clinical and research mission in an innovative way that informs disease paradigms and influences management guidelines in valvular heart disease.

Areas of Expertise

  • Cardiovascular Medicine
  • Heart Valve Diseases
  • Heart Valve Center
  • Heart and Vascular