Jonathan D. Brown, MD

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Assistant Professor of Medicine, Division of Cardiovascular Medicine

Research Description

Inflammation and stress signaling are critical determinants of cardiovascular and metabolic disease. Ultimately, these pathways converge in the nucleus to change chromatin structure and activate pathologic gene expression. A primary focus of the lab is to study how specific transcription factors and coregulators control these abnormal gene expression programs in cardiometabolic disease. In particular, the lab seeks to understand how chromatin-dependent signaling drives transcriptional programs that change cell state.  

Brief Description

Dr. Jonathan Brown is a cardiologist and basic scientist studying transcriptional mechanisms relevant to the pathogenesis of obesity, diabetes mellitus, and atherosclerosis. A central premise of his research involves a deeper understanding of the gene regulatory networks controlling disease pathogenesis to identify novel therapeutic targets to treat these prevalent and often fatal conditions. More specifically, Dr. Brown aims to study how chromatin regulators—as determinants of enhancer function and transcription—are involved in driving pathologic gene expression programs that alter vascular cell and adipose tissue function and result in cardiovascular disease and metabolic dysfunction. Because of his interest in the interplay among inflammation, metabolic disease, and atherogenesis, he is pursuing overlapping areas of investigation examining (1) how proinflammatory activation of vascular endothelium and macrophages drives enhancer remodeling and gene activation through the bromodomain and extra-terminal (BET) bromodomain proteins (BRD2, BRD3 and BRD4) and (2) how BET proteins control adipocyte plasticity and differentiation relevant for obesity and systemic metabolic diseases.

Email
jonathan.d.brown@vumc.org

Education

MD - New York Medical College

Clinical interest

Areas of Expertise

  • General Cardiology
  • Preventive Cardiology
  • Management of Hyperlipidemia

Board and Certifications

Cardiovascular Disease 2006