Matt Alexander, MD, PhD

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Assistant Professor of Medicine, Division of Clinical Pharmacology

Research Description

Dr. Alexander’s laboratory is focused on the role of adaptive immunity in the pathogenesis of hypertension and associated cardiovascular disease. Current projects are focused on the role of counter-regulatory immune mechanisms in hypertension, including determining the role of novel regulatory T cell subsets in the pathogenesis of hypertension and microvascular dysfunction. We perform cutting edge basic and translational research integrating vascular biology and immunology using a variety of approaches including molecular biology, physiology, highly dimensional single cell analysis, and human genetics. Our laboratory is also integrated with the translational research infrastructure in the Divisions of Clinical Pharmacology and Cardiovascular Medicine to enable novel studies on human tissues and cells. Ultimately, the goal of Alexander laboratory is to fundamentally advance our understanding of hypertension and related cardiovascular diseases to develop new therapies for the benefit of the tremendous number of individuals affected by these conditions.
Brief Description

Matt grew up in Kernersville, North Carolina and attended Duke University for his undergraduate studies.  He completed the MSTP program at the University of Virginia.  His thesis work focused on the role of inflammation in atherosclerotic plaque development, in particular the role of interleukin-1 in atherosclerotic plaque stability and in smooth muscle cell phenotypic switching.  Matt has completed his Internal Medicine training at Vanderbilt and is currently a fellow in Cardiovascular Medicine, with a long-term goal of improving our understanding of the role of inflammation in vascular disease development as a physician-scientist.



MD, PhD - University of Virginia School of Medicine
BS - Duke University

Clinical interest

Cardiovascular Medicine, Advanced Hypertension