Model for tumor-specific CD8 T-cell differentiation and dysfunction in tumors

Model for tumor-specific CD8 T-cell differentiation and dysfunction in tumors

Liver carcinogenesis in ASTxCre-ERT2 mice. Hematoxylin and eosin (H&E) staining of liver sections collected at D10, and D34 after Tam treatment.

Liver carcinogenesis in ASTxCre-ERT2 mice. Hematoxylin and eosin (H&E) staining of liver sections collected at D10, and D34 after Tam treatment.

Vanderbilt University Medical Center, main campus

Vanderbilt University Medical Center, main campus

You can always find entertainment, any evening in Music City Nashville, TN.

You can always find entertainment, any evening in Music City Nashville, TN.

Dr. Phililp and Ms. Anzarova at the ultra centrifuge preparing samples- cropped

Dr. Phililp and Ms. Anzarova at the ultra centrifuge preparing samples- cropped

Dr. Phililp and Ms. Anzarova discussing experimental protocols at the bench.

Dr. Phililp and Ms. Anzarova discussing experimental protocols at the bench.

Genomic and Non-Genomic Alterations in Cancer Evolution

Genomic and Non-Genomic Alterations in Cancer Evolution

Cancer cell surrounded by killer T cells

Cancer cell surrounded by killer T cells

Music City riverfront at twilight

Music City riverfront at twilight

Aerial view of Vanderbilt

Aerial view of Vanderbilt

Aerial view of VUMC

Aerial view of VUMC

Aerial view of Vanderbilt with heliports

Aerial view of Vanderbilt with heliports

Aerial view of Vanderbilt with heliports

Aerial view of Vanderbilt with heliports

Philip Lab Home

The Philip Lab studies immune system interactions with cancers. Tumor-reactive T cells are often found in patients’ tumors, however the tumors grow unimpeded; thus the T cells have been rendered dysfunctional. The overall goal of our laboratory is to understand how tumor-specific T cells become dysfunctional. We use genetically-engineered mouse models where we can track tumor-specific T cells as they differentiate in developing tumors and dissect the immunophenotypic, functional, transcriptional, and epigenetic properties of T cells using flow cytometry and next-generation sequencing. By unraveling the molecular pathways that lead to T cell dysfunction in cancer, we can devise new strategies for cancer immunotherapy.