Center for Mucosal Inflammation and Cancer (CMIC)

Many cancers have their root in chronic inflammation, and this is especially noted in the GI tract. The benchmark for this association is the Helicobacter pylori-induced cascade from gastritis to intestinal metaplasia to dysplasia to carcinoma. 

Other examples where inflammation is directly implicated in carcinogenesis include esophageal carcinoma, colitis-associated carcinoma, cholangiocarcinoma, hepatocellular carcinoma, and pancreatic cancer. With the explosion of new insights related to the microbiome and the metabolome, we are at a crossroads. 

With expertise in microbiology, immunology, inflammation, and carcinogenesis, pertaining to Helicobacter pylori-induced immune dysregulation and gastric cancer, inflammatory bowel disease, and other forms of mucosal inflammation, the CMIC strives to seek a comprehensive understanding of the relationship between inflammation and cancer.