Hawiger Lab Research Projects

 


Project 1: The Nuclear Transport Checkpoint Inhibitors (NTCIs) for intracellular therapy of inflammation

  • Design, development, and functional studies of selective nuclear blockade in inflammation-mediated allergic, autoimmune, metabolic, and microbial diseases

Project 2: Sepsis Activation of Thousands of Genes in the Lungs, Kidneys, Heart, Liver, Spleen, and Brain

  • Genomic analysis and control by the Selective Nuclear Blockade with cell-penetrating NTCIs

Project 3: Atopic Dermatitis (Eczema) Genomic Mechanism and Control

  • Topical treatment with cell-penetrating NTCIs of eczema and other inflammatory skin diseases (currently in Phase 2 Clinical Trial for mild to moderate Atopic Dermatitis (NCT04313400)

Project 4: Intracellular Protein Therapy as an Alternative to Gene Therapy

  • Design, development, and functional studies of recombinant intracellular proteins to replace their genetically-defective homologs

Project 5: NTCI attenuates autoimmune response in the pancreatic islets and reduces occurrence of Type 1 Diabetes

Project 6: NTCI reduces Metabolic Syndrome-induced hypersensitivity to microbial endotoxin

Past Projects

 

  • Nuclear Transport of Proinflammatory and Metabolic Transcription Factors
  • Extracellular and Intracellular Inhibition of the Integrin Function
  • Innate Immunity Adaptors (MyD88 and SARM) Structure and Function