Hawiger Lab Research Projects
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Project 1: The Nuclear Transport Checkpoint Inhibitors (NTCIs) for intracellular therapy of inflammation
Design, development, and functional studies of selective nuclear blockade in inflammation-mediated allergic, autoimmune, metabolic, and microbial diseases
Project 2: Sepsis Activation of Thousands of Genes in the Lungs, Kidneys, Heart, Liver, Spleen, and Brain
Genomic analysis and control by the Selective Nuclear Blockade with cell-penetrating NTCIs
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Project 3: Atopic Dermatitis (Eczema) Genomic Mechanism and Control
Topical treatment with cell-penetrating NTCIs of eczema and other inflammatory skin diseases (currently in Phase 2 Clinical Trial for mild to moderate Atopic Dermatitis (NCT04313400)
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Project 4: Intracellular Protein Therapy as an Alternative to Gene Therapy
Design, development, and functional studies of recombinant intracellular proteins to replace their genetically-defective homologs
Past Projects
- Nuclear Transport of Proinflammatory and Metabolic Transcription Factors
- Extracellular and Intracellular Inhibition of the Integrin Function
- Innate Immunity Adaptors (MyD88 and SARM) Structure and Function