Keith Wilson Lab

Gastrointestinal mucosal inflammation 
and carcinogenesis research 

The Keith Wilson Lab studies the host immune response to the gastric pathogen Helicobacter pylori that causes peptic ulcer disease and gastric cancer. This includes the innate immune response in macrophages and the identification of ways that this response is ineffective.  

We have also elucidated mechanisms whereby epithelial responses are inappropriate, leading to risk for cancer development. We study novel mechanisms for inflammation and cellular/DNA damage, which leads to increased cancer risk.  

We also study inflammatory bowel disease (IBD) and colorectal cancer (CRC). Our goal is to develop new potential therapies for IBD through improved understanding of disease pathogenesis, and new strategies to prevent CRC.