TB is closely linked to HIV; HIV has been a key contributor to the TB epidemic. People with living with M. tuberculosis and HIV infection are significantly more likely to develop TB than persons who are HIV-negative. To control TB in high HIV-prevalence settings, it is imperative to coordinate efforts for TB and HIV control. 

Vanderbilt collaborates with international organizations and performs studies in population-based cohorts to identify ways to reduce the burden of TB among persons living with HIV.

Active Projects:

  • International Epidemiologic Databases to Evaluate AIDS (IeDEA), NIH
    • Caribbean, Central, and South America network for HIV Epidemiology (CCASAnet); Argentina, Brazil, Chile, Haiti, Honduras, Mexico, Peru; PIs – Jessica Castilho, Stephany Duda, Pedro Cahn (Argentina); NIH U01AI069923
    • The North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD); Nashville, TN; PIs – Richard Moore (JHU), Keri Althoff (JHU), Timothy Sterling (VUMC Site PI); NIH U01AI069918
  • Harmonist: A Scalable Toolkit for Standardizing and Coordinating Data Sharing Across International Research Networks (R24); PI - Stephany Duda; NIH R24AI124872
  • Regional Prospective Observational Research for Tuberculosis (RePORT)- South Africa; PIs – Mark Hatherill (South Africa), Timothy Sterling; CRDF Global
  • AIDS Clinical Trials Group (ACTG) for Research on Therapeutics for HIV and Related Infections [TSG TB] (UM1); PIs- Judith Currier (UCLA) Kelly Dooley (VUMC); NIH UM1AI068636
  • Statistical methods for correlated outcome and covariate errors in studies of HIV/AIDS; South America and East Africa; PI – Bryan Shepherd; NIH R01AI131771
  • The Antiretroviral Therapy Cohort Collaboration (ART-CC); North America and Europe; PI – Jonathan Sterne, Timothy Sterling; NIH U01AA026209
  • Cohort representativeness and country-level differences among RePORT and IeDEA TB-SRN networks; PI – Timothy Sterling; CRDF Global
  • Retaining relevance: extending clinical retention measures to improve their utility in describing HIV care engagement in the United States; PI – Peter Rebeiro; NIH R01AI177010
  • Harnessing big data to arrest the HIV/HCV/opioid syndemic in the rural and urban South; PI – Peter Rebeiro; NIH R01DA057129

Completed Projects:

  • Associative BRICS Research in COVID-19 and Tuberculosis (ABRICOT); PIs - Valeria Rolla (Brazil), Timothy Sterling (VUMC); CRDF Global
  • Avante: Towards Epidemic Control, improving TB/HIV diagnosis and care in Mozambique; PI – Bill Wester; CDC/PEPFAR
  • Immune activation and dysglycemia in tuberculosis patients with and without HIV; South Africa; PIs – Yuri van der Heijden, John Koethe, Al Leslie (South Africa); CRDF Global
  • Predictors of treatment toxicity, failure, and relapse in HIV-related tuberculosis; Brazil; PIs – Timothy Sterling, Valeria Rolla (Brazil); NIH R01AI120790
  • RePORT International Data Harmonization; PIs - Timothy Sterling, Stephany Duda; CRDF Global