Jonathan D. Mosley, MD, PhD, is an Associate Professor in the Division of Clinical Pharmacology, Department of Medicine, at Vanderbilt University Medical Center. He is interested in examining how polygenic variation underlying complex human phenotypes and diseases can inform the practice of clinical medicine with respect to risk stratification, identifying vulnerable populations and guiding clinical care.
Dr. Mosley is a clinically trained scientist with a background in mathematics, information systems development and epidemiology and doctoral training in molecular and mouse models of mammary gland tumorigenesis. His research interests include identifying translational applications of measures polygenic variation to clinical medicine to improve health care delivery, reduce unnecessary health care utilization and improve risk stratification. This work typically leverages data from electronic health record (EHR) data sources and epidemiological studies. Content areas of interest include metabolomics, proteomics, clinical biomarkers and cardiac and other diseases.
Key Research Area
Genetics
Grants
R01GM130791, 09/01/2019-06/30/2024, NIH/NIGMS, Leveraging common genetic variation to reduce misclassification of non-diseased individuals and unnecessary health care utilization attributable to surrogate biomarkers
R01HL142856, 04/01/2019-03/31/2024, NIH/NHLBI, Virtual metabolomics as a discovery tool for novel cardiometabolic disease biology Cardiometabolic diseases
Honors and Awards
- 2023: Clinical Pharmacology Faculty Teaching Award, VUMC
- 2022: Circulation outstanding reviewer recognition
- 2021: Manuscript selected among top 10 genomic medicine papers by the Genomic Medicine Working Group, National Advisory Council of NHGRI
- 2020: Fellow of the American Heart Association
- 2020: Clinical Pharmacology Faculty Teaching Award, VUMC