Vickers Lab Publications

2022

• Michell DL, Allen RM, Cavnar AB, Contreras DM, Yu M, Semler EM, Massick C, Raby CA, Castleberry M, Ramirez MA, Zhu W, May-Zhang L, Ifrim A, Carr JJ, Terry JG, Schwendeman A, Davies SS, Sheng Q, Linton MF, Vickers KC. Elucidation of physico-chemical principles of high-density lipoprotein-small RNA binding interactions. The Journal of biological chemistry. 2022 Jun 1; 101952 p. PMID: 35447119 [PubMed]

2021

• Vickers KC, Michell DL. HDL-small RNA Export, Transport, and Functional Delivery in Atherosclerosis. Current atherosclerosis reports. 2021 Dec 13; 38 p. PMID: 33983531 [PubMed]PMC8455070 NIHMSID: NIHMS1739723.
• Abner JJ, Franklin JL, Clement MA, Hinger SA, Allen RM, Liu X, Kellner S, Wu J, Karijolich J, Liu Q, Vickers KC, Dedon P, Weaver AM, Coffey RJ, Patton JG. Depletion of METTL3 alters cellular and extracellular levels of miRNAs containing mA consensus sequences. Heliyon. 2021 Dec 1; e08519. PMID: 34934837 [PubMed]PMC8654799
• Aggarwal G, May-Zhang LS, Yermalitsky V, Dikalov S, Voynov MA, Amarnath V, Kon V, Linton MF, Vickers KC, Davies SS. Myeloperoxidase-induced modification of HDL by isolevuglandins inhibits paraoxonase-1 activity. The Journal of biological chemistry. 2021 Dec 1; 101019 p. PMID: 34331945 [PubMed]PMC8390528
• Wang Y, Niu A, Pan Y, Cao S, Terker AS, Wang S, Fan X, Toth CL, Ramirez Solano MA, Michell DL, Contreras D, Allen RM, Zhu W, Sheng Q, Fogo AB, Vickers KC, Zhang MZ, Harris RC. Profile of Podocyte Translatome During Development of Type 2 and Type 1 Diabetic Nephropathy Using Podocyte-Specific TRAP mRNA RNA-seq. Diabetes. 2021 Dec 1; 2377-2390. PMID: 34233930 [PubMed]PMC8576501
• Zhong J, Yang HC, Yermalitsky V, Shelton EL, Otsuka T, Wiese CB, May-Zhang LS, Banan B, Abumrad N, Huang J, Cavnar AB, Kirabo A, Yancey PG, Fogo AB, Vickers KC, Linton MF, Davies SS, Kon V. Kidney injury-mediated disruption of intestinal lymphatics involves dicarbonyl-modified lipoproteins. Kidney international. 2021 Dec 1; 585-596. PMID: 34102217 [PubMed]PMC8447488 NIHMSID: NIHMS1727186.
• Tao H, Yancey PG, Blakemore JL, Zhang Y, Ding L, Jerome WG, Brown JD, Vickers KC, Linton MF. Macrophage SR-BI modulates autophagy via VPS34 complex and PPARα transcription of Tfeb in atherosclerosis. The Journal of clinical investigation. 2021 Dec 1; PMID: 33661763 [PubMed]PMC8011903
• Tsujita M, Vaisman B, Chengyu L, Vickers KC, Okuhira KI, Braesch-Andersen S, Remaley AT. Apolipoprotein A-I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high-density lipoproteins assembled by ABCA1 and LCAT. FEBS letters. 2021 Dec 1; 773-788. PMID: 33020907 [PubMed]PMC7987658 NIHMSID: NIHMS1636400.
• Kon V, Yang HC, Smith LE, Vickers KC, Linton MF. High-Density Lipoproteins in Kidney Disease. International journal of molecular sciences. 2021 Jul 30; PMID: 34360965 [PubMed]PMC8348850
• Ormseth MJ, Solus JF, Sheng Q, Chen SC, Ye F, Wu Q, Oeser AM, Allen R, Raggi P, Vickers KC, Stein CM. Plasma miRNAs improve the prediction of coronary atherosclerosis in patients with rheumatoid arthritis. Clinical rheumatology. 2021 Jun 1; 2211-2219. PMID: 33389220 [PubMed]PMC8162679 NIHMSID: NIHMS1699150.

2020

• Michell DL, Zhao S, Allen RM, Sheng Q, Vickers KC. Pervasive Small RNAs in Cardiometabolic Research: Great Potential Accompanied by Biological and Technical Barriers. Diabetes. 2020 May 1; 813-822. PMID: 32312897 [PubMed]
• Sucre JMS, Vickers KC, Benjamin JT, Plosa EJ, Jetter CS, Cutrone A, Ransom M, Anderson Z, Sheng Q, Fensterheim BA, Ambalavanan N, Millis B, Lee E, Zijlstra A, Königshoff M, Blackwell TS, Guttentag SH. Hyperoxia Injury in the Developing Lung is Mediated by Mesenchymal Expression of Wnt5A. American journal of respiratory and critical care medicine. 2020 Feb 5. PMID: 32023086 [PubMed]
• Ormseth MJ, Solus JF, Sheng Q, Ye F, Song H, Wu Q, Guo Y, Oeser AM, Allen RM, Vickers KC, Stein CM. The Endogenous Plasma Small RNAome of Rheumatoid Arthritis. ACR open rheumatology. 2020 Feb 1; 97-105. PMID: 31913579 [PubMed]PMC7011423
• Hill N, Michell DL, Ramirez-Solano M, Sheng Q, Pusey C, Vickers KC, Woollard KJ. Glomerular endothelial derived vesicles mediate podocyte dysfunction: A potential role for miRNA. PloS one. e0224852. PMID: 32214346 [PubMed]PMC7098579

2019

• Rogers LM, Serezani CH, Eastman AJ, Hasty AH, Englund-Ögge L, Jacobsson B, Vickers KC, Aronoff DM. Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages. Placenta. 2019 Dec 15; 45-51. PMID: 32056551 [PubMed]PMC7034939 NIHMSID: NIHMS1546308.
• Rodriguez A, Trigatti BL, Mineo C, Knaack D, Wilkins JT, Sahoo D, Asztalos BF, Mora S, Cuchel M, Pownall HJ, Rosales C, Bernatchez P, Ribeiro Martins da Silva A, Getz GS, Barber JL, Shearer GC, Zivkovic AM, Tietge UJF, Sacks FM, Connelly MA, Oda MN, Davidson WS, Sorci-Thomas MG, Vaisar T, Ruotolo G, Vickers KC, Martel C. Proceedings of the Ninth HDL (High-Density Lipoprotein) Workshop: Focus on Cardiovascular Disease. Arteriosclerosis, thrombosis, and vascular biology. 2019 Dec 1; 2457-2467. PMID: 31597448 [PubMed]PMC6937204 NIHMSID: NIHMS1540642.
• Zaborowski MP, Cheah PS, Zhang X, Bushko I, Lee K, Sammarco A, Zappulli V, Maas SLN, Allen RM, Rumde P, György B, Aufiero M, Schweiger MW, Lai CP, Weissleder R, Lee H, Vickers KC, Tannous BA, Breakefield XO. Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles. Scientific reports. 2019 Nov 22; 17387 p. PMID: 31758005 [PubMed]PMC6874653
• Tabet F, Lee S, Zhu W, Levin MG, Toth CL, Cuesta Torres LF, Vinh A, Kim HA, Chu HX, Evans MA, Kuzmich ME, Drummond GR, Remaley AT, Rye KA, Sobey CG, Vickers KC. microRNA-367-3p regulation of GPRC5A is suppressed in ischemic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2019 Jul 11. 271678X19858637. PMID: 31296130 [PubMed]
• Cuesta Torres LF, Zhu W, Öhrling G, Larsson R, Patel M, Wiese CB, Rye KA, Vickers KC, Tabet F. High-density lipoproteins induce miR-223-3p biogenesis and export from myeloid cells: Role of scavenger receptor BI-mediated lipid transfer. Atherosclerosis. 2019 Jul 1; 20-29. PMID: 31096070 [PubMed]
• Sedgeman LR, Michell DL, Vickers KC. Integrative roles of microRNAs in lipid metabolism and dyslipidemia. Current opinion in lipidology. 2019 Jun 1; 165-171. PMID: 30985366 [PubMed]
• Ormseth MJ, Solus JF, Sheng Q, Ye F, Wu Q, Guo Y, Oeser AM, Allen RM, Vickers KC, Stein CM. Development and Validation of a microRNA Panel to Differentiate between Patients with Rheumatoid Arthritis or Systemic Lupus Erythematosus and Controls. The Journal of rheumatology. 2019 May 15. PMID: 31092710 [PubMed]
• Zhang Q, Higginbotham JN, Jeppesen DK, Yang YP, Li W, McKinley ET, Graves-Deal R, Ping J, Britain CM, Dorsett KA, Hartman CL, Ford DA, Allen RM, Vickers KC, Liu Q, Franklin JL, Bellis SL, Coffey RJ. Transfer of Functional Cargo in Exomeres. Cell reports. 2019 Apr 16; 940-954.e6. PMID: 30956133 [PubMed]PMC6559347 NIHMSID: NIHMS1527182.
• Sedgeman LR, Beysen C, Ramirez Solano MA, Michell DL, Sheng Q, Zhao S, Turner S, Linton MF, Vickers KC. Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion. Scientific reports. 2019 Mar 7; 3803 p. PMID: 30846744 [PubMed]PMC6405899
• Wiese CB, Zhong J, Xu ZQ, Zhang Y, Ramirez Solano MA, Zhu W, Linton MF, Sheng Q, Kon V, Vickers KC. Dual inhibition of endothelial miR-92a-3p and miR-489-3p reduces renal injury-associated atherosclerosis. Atherosclerosis. 2019 Mar 1; 121-131. PMID: 30731284 [PubMed]
• Trujillo-Gonzalez I, Wang Y, Friday WB, Vickers KC, Toth CL, Molina-Torres L, Surzenko N, Zeisel SH. MicroRNA-129-5p is regulated by choline availability and controls EGF receptor synthesis and neurogenesis in the cerebral cortex. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 Mar 1; 3601-3612. PMID: 30521373 [PubMed]PMC6404558
• Babaev VR, Ding L, Zhang Y, May JM, Ramsey SA, Vickers KC, Linton MF. Loss of 2 Akt (Protein Kinase B) Isoforms in Hematopoietic Cells Diminished Monocyte and Macrophage Survival and Reduces Atherosclerosis in Ldl Receptor-Null Mice. Arteriosclerosis, thrombosis, and vascular biology. 2019 Feb 1; 156-169. PMID: 30567482 [PubMed]PMC6344270 NIHMSID: NIHMS1515971.
• Hung YH, Kanke M, Kurtz CL, Cubitt RL, Bunaciu RP, Zhou L, White PJ, Vickers KC, Hussain MM, Li X, Sethupathy P. MiR-29 Regulates Lipogenesis in the Liver and Circulating Triglyceride Levels in a Sirt1-Dependent Manner. Frontiers in physiology. 1367 p. PMID: 31736786 [PubMed]PMC6828850
• Hennessy EJ, Van Solingen C, Scacalossi KR, Ouimet M, Afonso MS, Prins J, Koelwyn GJ, Sharma M, Ramkhelawon B, Carpenter S, Busch A, Chernogubova E, Matic LP, Hedin U, Maegdefessel L, Caffrey BE, Hussein MA, Ricci EP, Temel RE, Garabedian MJ, Berger JS, Vickers KC, Kanke M, Sethupathy P, Teupser D, Holdt LM, Moore KJ. The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Nature metabolism. 2019 Jan 1; 98-110. PMID: 31410392 [PubMed]PMC6691505 NIHMSID: NIHMS1509876.

2018

• Sedgeman LR, Beysen C, Allen RM, Ramirez Solano MA, Turner SM, Vickers KC. Intestinal bile acid sequestration improves glucose control by stimulating hepatic miR-182-5p in type 2 diabetes. American journal of physiology. Gastrointestinal and liver physiology. 2018 Nov 1; G810-G823. PMID: 30160993 [PubMed]PMC6415711
• Li K, Rodosthenous RS, Kashanchi F, Gingeras T, Gould SJ, Kuo LS, Kurre P, Lee H, Leonard JN, Liu H, Lombo TB, Momma S, Nolan JP, Ochocinska MJ, Pegtel DM, Sadovsky Y, Sánchez-Madrid F, Valdes KM, Vickers KC, Weaver AM, Witwer KW, Zeng Y, Das S, Raffai RL, Howcroft TK. Advances, challenges, and opportunities in extracellular RNA biology: insights from the NIH exRNA Strategic Workshop. JCI insight. 2018 Apr 5; PMID: 29618663 [PubMed]PMC5928855
• Allen RM, Zhao S, Ramirez Solano MA, Zhu W, Michell DL, Wang Y, Shyr Y, Sethupathy P, Linton MF, Graf GA, Sheng Q, Vickers KC. Bioinformatic analysis of endogenous and exogenous small RNAs on lipoproteins. Journal of extracellular vesicles. 1506198 p. PMID: 30128086 [PubMed]PMC6095027

2017

• Guo Y, Strickland SA, Mohan S, Li S, Bosompem A, Vickers KC, Zhao S, Sheng Q, Kim AS. MicroRNAs and tRNA-derived fragments predict the transformation of myelodysplastic syndromes to acute myeloid leukemia. Leukemia & lymphoma. 2017 Sep 1; 1-15. PMID: 28084850 [PubMed]PMC5505168 NIHMSID: NIHMS852843.
• Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC. Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation. Cell metabolism. 2017 Jun 6; 1362-1373.e5. PMID: 28591638 [PubMed]PMC5572896 NIHMSID: NIHMS880297.

2016

• Michell DL, Vickers KC. HDL and microRNA therapeutics in cardiovascular disease. Pharmacology & therapeutics. 2016 Dec 1; 43-52. PMID: 27595929 [PubMed]PMC5140688 NIHMSID: NIHMS816881.
• Ormseth MJ, Yancey PG, Yamamoto S, Oeser AM, Gebretsadik T, Shintani A, Linton MF, Fazio S, Davies SS, Roberts LJ, Vickers KC, Raggi P, Kon V, Stein CM. Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis. IJC metabolic & endocrine. 2016 Dec 1; 6-11. PMID: 28243578 [PubMed]PMC5325720 NIHMSID: NIHMS814033.
• Michell DL, Allen RM, Landstreet SR, Zhao S, Toth CL, Sheng Q, Vickers KC. Isolation of High-density Lipoproteins for Non-coding Small RNA Quantification. Journal of visualized experiments : JoVE. 2016 Nov 28; PMID: 27929461 [PubMed]PMC5226318 NIHMSID: NIHMS764766.
• Beavers KR, Werfel TA, Shen T, Kavanaugh TE, Kilchrist KV, Mares JW, Fain JS, Wiese CB, Vickers KC, Weiss SM, Duvall CL. Porous Silicon and Polymer Nanocomposites for Delivery of Peptide Nucleic Acids as Anti-MicroRNA Therapies. Advanced materials (Deerfield Beach, Fla.). 2016 Sep 1; 7984-7992. PMID: 27383910 [PubMed]PMC5152671 NIHMSID: NIHMS832688.
• Ormseth MJ, Yancey PG, Solus JF, Louis Bridges S, Curtis JR, Linton MF, Fazio S, Davies SS, Roberts LJ, Vickers KC, Kon V, Michael Stein C, . Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein-Enriched Serum in Rheumatoid Arthritis. Arthritis & rheumatology (Hoboken, N.J.). 2016 Sep 1; 2099-105. PMID: 26991245 [PubMed]PMC5001900 NIHMSID: NIHMS771619.
• Michell DL, Vickers KC. Lipoprotein carriers of microRNAs. Biochimica et biophysica acta. 2016 Jan 1; 2069-2074. PMID: 26825691 [PubMed]PMC4959968 NIHMSID: NIHMS758037.

2015

• Selitsky SR, Dinh TA, Toth CL, Kurtz CL, Honda M, Struck BR, Kaneko S, Vickers KC, Lemon SM, Sethupathy P. Transcriptomic Analysis of Chronic Hepatitis B and C and Liver Cancer Reveals MicroRNA-Mediated Control of Cholesterol Synthesis Programs. MBio. 2015 Dec 8; e01500-15. PMID: 26646011 [PubMed]PMC4676282
• Ormseth MJ, Solus JF, Vickers KC, Oeser AM, Raggi P, Stein CM. Utility of Select Plasma MicroRNA for Disease and Cardiovascular Risk Assessment in Patients with Rheumatoid Arthritis. The Journal of rheumatology. 2015 Oct 1; 1746-1751. PMID: 26233505 [PubMed]PMC4592411 NIHMSID: NIHMS704680.
• Guo Y, Bosompem A, Mohan S, Erdogan B, Ye F, Vickers KC, Sheng Q, Zhao S, Li CI, Su PF, Jagasia M, Strickland SA, Griffiths EA, Kim AS. Transfer RNA detection by small RNA deep sequencing and disease association with myelodysplastic syndromes. BMC genomics. 2015 Sep 24; 727 p. PMID: 26400237 [PubMed]PMC4581457
• Han L, Vickers KC, Samuels DC, Guo Y. Alternative applications for distinct RNA sequencing strategies. Briefings in bioinformatics. 2015 Jul 1; 629-39. PMID: 25246237 [PubMed]PMC4542857
• Luthi AJ, Lyssenko NN, Quach D, McMahon KM, Millar JS, Vickers KC, Rader DJ, Phillips MC, Mirkin CA, Thaxton CS. Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein. Journal of lipid research. 2015 May 1; 972-85. PMID: 25652088 [PubMed]PMC4409287
• Kaseda R, Jabs K, Hunley TE, Jones D, Bian A, Allen RM, Vickers KC, Yancey PG, Linton MF, Fazio S, Kon V. Dysfunctional high-density lipoproteins in children with chronic kidney disease. Metabolism: clinical and experimental. 2015 Feb 1; 263-73. PMID: 25467845 [PubMed]PMC4277938 NIHMSID: NIHMS642087.
• Vickers KC, Roteta LA, Hucheson-Dilks H, Han L, Guo Y. Mining diverse small RNA species in the deep transcriptome. Trends in biochemical sciences. 2015 Jan 1; 4-7. PMID: 25435401 [PubMed]PMC4362530 NIHMSID: NIHMS670302.

2014

• Babaev VR, Hebron KE, Wiese CB, Toth CL, Ding L, Zhang Y, May JM, Fazio S, Vickers KC, Linton MF. Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice. Journal of lipid research. 2014 Nov 1; 2296-308. PMID: 25240046 [PubMed]PMC4617132
• Vickers KC, Landstreet SR, Levin MG, Shoucri BM, Toth CL, Taylor RC, Palmisano BT, Tabet F, Cui HL, Rye KA, Sethupathy P, Remaley AT. MicroRNA-223 coordinates cholesterol homeostasis. Proceedings of the National Academy of Sciences of the United States of America. 2014 Oct 7; 14518-23. PMID: 25246565 [PubMed]PMC4210029
• Allen RM, Vickers KC. Coenzyme Q10 increases cholesterol efflux and inhibits atherosclerosis through microRNAs. Arteriosclerosis, thrombosis, and vascular biology. 2014 Sep 1; 1795-7. PMID: 25142877 [PubMed]PMC4142520 NIHMSID: NIHMS610618.
• Kurtz CL, Peck BC, Fannin EE, Beysen C, Miao J, Landstreet SR, Ding S, Turaga V, Lund PK, Turner S, Biddinger SB, Vickers KC, Sethupathy P. MicroRNA-29 fine-tunes the expression of key FOXA2-activated lipid metabolism genes and is dysregulated in animal models of insulin resistance and diabetes. Diabetes. 2014 Sep 1; 3141-8. PMID: 24722248 [PubMed]PMC4141370
• Tabet F, Vickers KC, Cuesta Torres LF, Wiese CB, Shoucri BM, Lambert G, Catherinet C, Prado-Lourenco L, Levin MG, Thacker S, Sethupathy P, Barter PJ, Remaley AT, Rye KA. HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells. Nature communications. 2014 Feb 28; 3292 p. PMID: 24576947 [PubMed]PMC4189962 NIHMSID: NIHMS576607.
• Vickers KC, Remaley AT. HDL and cholesterol: life after the divorce? Journal of lipid research. 2014 Jan 1; 4-12. PMID: 23515282 [PubMed]PMC3927467

2013

• Vickers KC, Moore KJ. Small RNA overcomes the challenges of therapeutic targeting of microsomal triglyceride transfer protein. Circulation research. 2013 Nov 8; 1189-91. PMID: 24201112 [PubMed]PMC4043302 NIHMSID: NIHMS576610.
• Pavlatou MG, Vickers KC, Varma S, Malek R, Sampson M, Remaley AT, Gold PW, Skarulis MC, Kino T. Circulating cortisol-associated signature of glucocorticoid-related gene expression in subcutaneous fat of obese subjects. Obesity (Silver Spring, Md.). 2013 May 1; 960-7. PMID: 23784897 [PubMed]PMC4199221 NIHMSID: NIHMS632619.
• Vickers KC, Sethupathy P, Baran-Gale J, Remaley AT. Complexity of microRNA function and the role of isomiRs in lipid homeostasis. Journal of lipid research. 2013 May 1; 1182-91. PMID: 23505317 [PubMed]PMC3622316