Recent publications from the lab
- Schmeckpeper J, Kim K, Berge A, Bulsara PA, Knollmann BC. Mavacamten-like myosin inhibitor MYK-581 reduces risk of atrial fibrillation induction in murine model of hypertrophic cardiomyopathy. Heart Rhythm. 2026 Feb 16:S1547-5271(26)00130-X. doi: 10.1016/j.hrthm.2026.02.012. Epub ahead of print. PMID: 41707765.
- Do TQ, Blackwell DJ, Smith AN, Thorpe MP, Rebbeck RT, Laver DR, Johnston JN, Knollmann BC. Introduction of a single carboxylic acid converts the cyclic oligomeric depsipeptide ent-verticilide from a ryanodine receptor 2 (RyR2) inhibitor to RyR2 activator. Mol Pharmacol. 2025 Dec;107(12):100086. doi: 10.1016/j.molpha.2025.100086. Epub 2025 Oct 31. PMID: 41337857; PMCID: PMC12799544.
- Egly CL, Shen A, Do TQ, Tellet Cabiya C, Ritschel PA, Woo S, Ku M, Delisle BP, Kroncke BM, Knollmann BC. High-throughput screens identify genotype-specific therapeutics for channelopathies. JCI Insight. 2025 Sep 30;10(22):e191697. doi: 10.1172/jci.insight.191697. PMID: 41026531; PMCID: PMC12643509.
- El-Harasis MA, Yoneda ZT, Varghese B, Grauherr D, Crawford DM, Schmeckpeper J, Williams HL, Ye F, Sun L, Tandri H, Richardson T, Kanagasundram A, Davogustto G, Roden D, Mantinan M, Pretorius M, Billings FT, Siegrist K, Akers WS, Stevenson WG, Knollmann BC, Shoemaker MB. Ryanodine Receptor Inhibition with Dantrolene Prevents Ventricular Tachycardia Induction in Patients with Structural Heart Disease - A Randomized Controlled Trial. medRxiv [Preprint]. 2025 Aug 19:2025.08.17.25333868. doi: 10.1101/2025.08.17.25333868. PMID: 40894163; PMCID: PMC12393640.
- Blackwell DJ, Knollmann BC. Finding the right balance of RyR2 phosphorylation for arrhythmia prevention. Nat Cardiovasc Res. 2025 Aug;4(8):962-963. doi: 10.1038/s44161-025-00701-6. PMID: 40797045.
- Do TQ, Knollmann BC. Inhibitors of Intracellular RyR2 Calcium Release Channels as Therapeutic Agents in Arrhythmogenic Heart Diseases. Annu Rev Pharmacol Toxicol. 2025 Jan;65(1):443-463. doi: 10.1146/annurev-pharmtox-061724-080739. Epub 2024 Dec 17. PMID: 39374431.