Publications

Moore RE, Spicer SK, Lu J, Chambers SA, Noble KN, Lochner J, Christofferson RC, Vasco KA, Manning SD, Townsend SD, Gaddy JA. The utility of human milk oligosaccharides against Group B Streptococcus infections of reproductive tissues and cognate adverse pregnancy outcomes. ACS Central Science. 2023.
Avery TM, Boone RL, Lu J, Spicer SK, Guevara MA, Moore RE, Chambers SA, Manning SD, Dent L, Marshall D, Damo SM, Townsend SD, Gaddy JA. Analysis of Antimicrobial and Antibiofilm Activity of Human Milk Lactoferrin Compared to Bovine Lactoferrin against Multidrug Resistant and Susceptible Acinetobacter baumannii Clinical Isolates. ACS Infect Dis. 2021. 7(8):2116-2126. PMCID: PMC8577213.

Chambers SA, Moore RE, Craft KM, Thomas HC, Das R, Manning SD, Codreanu SG, Sherrod SD, Aronoff DM, McLean JA, Gaddy JA, Townsend SD. A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim. mBio. 2020. 11(2):e00076-20. PMCID: PMC7078465.
Ackerman DL, Doster RS, Weitkamp JH, Aronoff DM, Gaddy JA, Townsend SD. Human Milk Oligosaccharides Exhibit Antimicrobial and Antibiofilm Properties against Group B Streptococcus. ACS Infect Dis. 2017. 3(8):595-605. PMCID: PMC5868341.

Stephens VR, Moore RE, Spicer SK, Talbert JA, Lu J, Chinni R, Chambers SA, Townsend SD, Manning SD, Rogers LM, Aronoff DM, Vue Z, Neikirk K, Hinton AO Jr, Damo SM, Noble KN, Eastman AJ, McCallister MM, Osteen KG, Gaddy JA. Environmental Toxicant Exposure Paralyzes Human Placental Macrophage Responses to Microbial Threat. ACS Infect Dis. 2023 Dec 8;9(12):2401-2408. DOI: 10.1021/acsinfecdis.3c00490
Sutton JA, Rogers LM, Dixon BREA, Kirk L, Doster R, Algood HM, Gaddy JA, Flaherty R, Manning SD, Aronoff DM. Protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus. Am J Reprod Immunol. 2019. 81(3):e13075. PMCID: PMC6459189. doi: 10.1111/aji.13075
Korir ML, Flaherty RA, Rogers LM, Gaddy JA, Aronoff DM, Manning SD. Investigation of the Role That NADH Peroxidase Plays in Oxidative Stress Survival in Group B Streptococcus. Front Microbiol. 2018. 9:2786. PMCID: PMC6255910. doi: 10.3389/fmicb.2018.02786

Doster RS, Sutton JA, Rogers LM, Aronoff DM, Gaddy JA. Streptococcus agalactiae Induces Placental Macrophages To Release Extracellular Traps Loaded with Tissue Remodeling Enzymes via an Oxidative Burst-Dependent Mechanism. mBio. 2018. 9(6):e02084-18. PMCID: PMC6247082. doi: 10.1128/mBio.02084-18
Rogers LM, Anders AP, Doster RS, Gill EA, Gnecco JS, Holley JM, Randis TM, Ratner AJ, Gaddy JA, Osteen K, Aronoff DM. Decidual stromal cell-derived PGE2 regulates macrophage responses to microbial threat. Am J Reprod Immunol. 2018. 80(4):e13032. PMCID: PMC6461368. doi: 10.1111/aji.13032

Lu J, Moore RE, Spicer SK, Doster RS, Guevara MA, Francis JD, Noble KN, Rogers LM, Talbert JA, Korir ML, Townsend SD, Aronoff DM, Manning SD, Gaddy JA. Streptococcus agalactiae npx Is Required for Survival in Human Placental Macrophages and Full Virulence in a Model of Ascending Vaginal Infection during Pregnancy. mBio. 2022. e0287022. PMID: 36409087. DOI: 10.1128/mbio.02870-22
Korir ML, Doster RS, Lu J, Guevara MA, Spicer SK, Moore RE, Francis JD, Rogers LM, Haley KP, Blackman A, Noble KN, Eastman AJ, Williams JA, Damo SM, Boyd KL, Townsend SD, Henrique Serezani C, Aronoff DM, Manning SD, Gaddy JA. Streptococcus agalactiae cadD alleviates metal stress and promotes intracellular survival in macrophages and ascending infection during pregnancy. Nat Commun. 202213(1):5392. PMCID: PMC9474517.  doi: 10.1038/s41467-022-32916-7

Noble K, Lu J, Guevara MA, Doster RS, Chambers SA, Rogers LM, Moore RE, Spicer SK, Eastman AJ, Francis JD, Manning SD, Rajagopal L, Aronoff DM, Townsend SD, Gaddy JA. Group B Streptococcus cpsE Is Required for Serotype V Capsule Production and Aids in Biofilm Formation and Ascending Infection of the Reproductive Tract during Pregnancy. ACS Infect Dis. 2021. 7(9):2686-2696. PMCID: PMC8588567. doi: 10.1021/acsinfecdis.1c00182
Kothary V, Doster RS, Rogers LM, Kirk LA, Boyd KL, Romano-Keeler J, Haley KP, Manning SD, Aronoff DM, Gaddy JA. Group B Streptococcus Induces Neutrophil Recruitment to Gestational Tissues and Elaboration of Extracellular Traps and Nutritional Immunity. Front Cell Infect Microbiol. 2017. 7:19. PMCID: PMC5289994. doi: 10.3389/fcimb.2017.00019