Dawn C. Newcomb, PhD

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Office Address:
1161 21st Avenue South , Medical Center North, Room / Suite 1227-B, Nashville, TN, TN 37232

Assistant Professor of Medicine, Division of Allergy, Pulmonary, and Critical Care Medicine

Assistant Professor, Department of Pathology, Microbiology and Immunology

Research Description

Our laboratory is focused on determining the role of sex hormones on innate lymphoid cell and T cell differentiation and cytokine expression, using asthma as our disease model. To study this, we utilize lymphocytes from the blood of healthy and asthmatic individuals as well as mouse models which mimic asthma. Findings from our laboratory will be important in determining why women are more likely to have asthma as adults compared to men and may provide new potential therapeutic targets for treating airway inflammation.

Clinical or Research Keywords:

T cells, innate lymphoid cells, asthma, allergy

Email
dawn.newcomb@vumc.org

Education

PhD Molecular & Integrative Physiology - University of Michigan, Ann Arbor, Michigan
BS, Chemistry - North Carolina State University, Raleigh, North Carolina

Publications

Stier MT, Goleniewska K, Cephus JY, Newcomb DC, Sherrill TP, Boyd KL, Bloodworth MH, Moore ML, Chen K, Kolls JK, Peebles RS. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral InfectionJ. Immunol [print-electronic]. 2017 Jul 7/15/2017; 199(2): 510-9. PMID: 28576981, PMCID: PMC5505788, PII: jimmunol.1601984, DOI: 10.4049/jimmunol.1601984, ISSN: 1550-6606. 

Fuseini H, Newcomb DCMechanisms Driving Gender Differences in AsthmaCurr Allergy Asthma Rep. 2017 Mar; 17(3): 19. PMID: 28332107, PII: 10.1007/s11882-017-0686-1, DOI: 10.1007/s11882-017-0686-1, ISSN: 1534-6315. 

Zhou W, Zhang J, Goleniewska K, Dulek DE, Toki S, Newcomb DC, Cephus JY, Collins RD, Wu P, Boothby MR, Peebles RS. Prostaglandin I2 Suppresses Proinflammatory Chemokine Expression, CD4 T Cell Activation, and STAT6-Independent Allergic Lung InflammationJ. Immunol [print-electronic]. 2016 Sep 9/1/2016; 197(5): 1577-86. PMID: 27456482, PMCID: PMC4992670, PII: jimmunol.1501063, DOI: 10.4049/jimmunol.1501063, ISSN: 1550-6606. 

Banathy A, Cheung-Flynn J, Goleniewska K, Boyd KL, Newcomb DC, Peebles RS, Komalavilas P. Heat Shock-Related Protein 20 Peptide Decreases Human Airway Constriction Downstream of ß2-Adrenergic ReceptorAm. J. Respir. Cell Mol. Biol. 2016 Aug; 55(2): 225-33. PMID: 26909644, PMCID: PMC4979360, DOI: 10.1165/rcmb.2015-0139OC, ISSN: 1535-4989. 

Toki S, Goleniewska K, Reiss S, Zhou W, Newcomb DC, Bloodworth MH, Stier MT, Boyd KL, Polosukhin VV, Subramaniam S, Peebles RS. The histone deacetylase inhibitor trichostatin A suppresses murine innate allergic inflammation by blocking group 2 innate lymphoid cell (ILC2) activationThorax [print-electronic]. 2016 Jul; 71(7): 633-45. PMID: 27071418, PMCID: PMC4941189, PII: thoraxjnl-2015-207728, DOI: 10.1136/thoraxjnl-2015-207728, ISSN: 1468-3296. 

Bloodworth MH, Newcomb DC, Dulek DE, Stier MT, Cephus JY, Zhang J, Goleniewska K, Kolls JK, Peebles RS. STAT6 Signaling Attenuates Interleukin-17-Producing ¿d T Cells during Acute Klebsiella pneumoniae InfectionInfect. Immun [electronic-print]. 2016 May; 84(5): 1548-55. PMID: 26953325, PMCID: PMC4862712, PII: IAI.00646-15, DOI: 10.1128/IAI.00646-15, ISSN: 1098-5522. 

Stier MT, Bloodworth MH, Toki S, Newcomb DC, Goleniewska K, Boyd KL, Quitalig M, Hotard AL, Moore ML, Hartert TV, Zhou B, McKenzie AN, Peebles RS. Respiratory syncytial virus infection activates IL-13-producing group 2 innate lymphoid cells through thymic stromal lymphopoietinJ. Allergy Clin. Immunol [print-electronic]. 2016 Apr 4/9/2016; PMID: 27156176, PII: S0091-6749(16)30080-X, DOI: 10.1016/j.jaci.2016.01.050, ISSN: 1097-6825. 

Newcomb DC, Cephus JY, Boswell MG, Fahrenholz JM, Langley EW, Feldman AS, Zhou W, Dulek DE, Goleniewska K, Woodward KB, Sevin CM, Hamilton RG, Kolls JK, Peebles RS. Estrogen and progesterone decrease let-7f microRNA expression and increase IL-23/IL-23 receptor signaling and IL-17A production in patients with severe asthmaJ. Allergy Clin. Immunol [print-electronic]. 2015 Oct; 136(4): 1025-1034.e11. PMID: 26242299, PMCID: PMC4600442, PII: S0091-6749(15)00840-4, DOI: 10.1016/j.jaci.2015.05.046, ISSN: 1097-6825. 

Zhou W, Toki S, Zhang J, Goleniewska K, Newcomb DC, Cephus JY, Dulek DE, Bloodworth MT, Stier MT, Polosuhkin V, Gangula RD, Mallal SA, Broide DH, Peebles RS. PGI2 Signaling Inhibits Group 2 Innate Lymphoid Cell ResponsesAm. J. Respir. Crit. Care Med [print-electronic]. 2015 Sep 9/17/2015; PMID: 26378386, DOI: 10.1164/rccm.201410-1793OC, ISSN: 1535-4970. 

Hotard AL, Lee S, Currier MG, Crowe JE, Sakamoto K, Newcomb DC, Peebles RS, Plemper RK, Moore ML. Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesisJ. Virol [print-electronic]. 2015 Jan; 89(1): 512-22. PMID: 25339762, PMCID: PMC4301159, PII: JVI.02472-14, DOI: 10.1128/JVI.02472-14, ISSN: 1098-5514. 

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signalingJ. Allergy Clin. Immunol [print-electronic]. 2014 Sep; 134(3): 698-705.e5. PMID: 25042746, PMCID: PMC4358822, PII: S0091-6749(14)00806-9, DOI: 10.1016/j.jaci.2014.06.004, ISSN: 1097-6825. 

Dulek DE, Newcomb DC, Goleniewska K, Cephus J, Zhou W, Reiss S, Toki S, Ye F, Zaynagetdinov R, Sherrill TP, Blackwell TS, Moore ML, Boyd KL, Kolls JK, Peebles RS. Allergic airway inflammation decreases lung bacterial burden following acute Klebsiella pneumoniae infection in a neutrophil- and CCL8-dependent mannerInfect. Immun [print-electronic]. 2014 Sep; 82(9): 3723-39. PMID: 24958709, PMCID: PMC4187810, PII: IAI.00035-14, DOI: 10.1128/IAI.00035-14, ISSN: 1098-5522. 

Dulek DE, Newcomb DC, Toki S, Goliniewska K, Cephus J, Reiss S, Bates JT, Crowe JE, Boyd KL, Moore ML, Zhou W, Peebles RS. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challengeJ. Virol [print-electronic]. 2014 Sep 9/1/2014; 88(17): 9655-72. PMID: 24920804, PMCID: PMC4136353, PII: JVI.03299-13, DOI: 10.1128/JVI.03299-13, ISSN: 1098-5514. 

Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signalingJ. Allergy Clin. Immunol [print-electronic]. 2014 Sep; 134(3): 698-705.e5. PMID: 25042746, PMCID: PMC4358822, PII: S0091-6749(14)00806-9, DOI: 10.1016/j.jaci.2014.06.004, ISSN: 1097-6825. 

Newcomb DC, Peebles RS. Th17-mediated inflammation in asthmaCurr. Opin. Immunol [print-electronic]. 2013 Dec; 25(6): 755-60. PMID: 24035139, PMCID: PMC3855890, PII: S0952-7915(13)00130-1, DOI: 10.1016/j.coi.2013.08.002, ISSN: 1879-0372. 

Sevin CM, Newcomb DC, Toki S, Han W, Sherrill TP, Boswell MG, Zhu Z, Collins RD, Boyd KL, Goleniewska K, Huckabee MM, Blackwell TS, Peebles RS. Deficiency of gp91phox inhibits allergic airway inflammationAm. J. Respir. Cell Mol. Biol. 2013 Sep; 49(3): 396-402. PMID: 23590311, PMCID: PMC3824054, DOI: 10.1165/rcmb.2012-0442OC, ISSN: 1535-4989. 

Newcomb DC, Boswell MG, Reiss S, Zhou W, Goleniewska K, Toki S, Harintho MT, Lukacs NW, Kolls JK, Peebles RS. IL-17A inhibits airway reactivity induced by respiratory syncytial virus infection during allergic airway inflammationThorax [print-electronic]. 2013 Aug; 68(8): 717-23. PMID: 23422214, PMCID: PMC3916091, PII: thoraxjnl-2012-202404, DOI: 10.1136/thoraxjnl-2012-202404, ISSN: 1468-3296. 

Toki S, Goleniewska K, Huckabee MM, Zhou W, Newcomb DC, Fitzgerald GA, Lawson WE, Peebles RS. PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cellsJ. Leukoc. Biol [print-electronic]. 2013 Jul; 94(1): 77-88. PMID: 23625201, PMCID: PMC3685021, PII: jlb.1112559, DOI: 10.1189/jlb.1112559, ISSN: 1938-3673. 

Newcomb DC, Boswell MG, Sherrill TP, Polosukhin VV, Boyd KL, Goleniewska K, Brody SL, Kolls JK, Adler KB, Peebles RS. IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasiaAm. J. Respir. Cell Mol. Biol. 2013 Jun; 48(6): 711-6. PMID: 23392574, PMCID: PMC3727878, PII: rcmb.2013-0017OC, DOI: 10.1165/rcmb.2013-0017OC, ISSN: 1535-4989. 

Newcomb DC, Boswell MG, Sherrill TP, Polosukhin VV, Boyd KL, Goleniewska K, Brody SL, Kolls JK, Adler KB, Peebles RS. IL-17A induces signal transducers and activators of transcription-6-independent airway mucous cell metaplasiaAm. J. Respir. Cell Mol. Biol. 2013 Jun; 48(6): 711-6. PMID: 23392574, PMCID: PMC3727878, PII: rcmb.2013-0017OC, DOI: 10.1165/rcmb.2013-0017OC, ISSN: 1535-4989. 

Tanjore H, Degryse AL, Crossno PF, Xu XC, McConaha ME, Jones BR, Polosukhin VV, Bryant AJ, Cheng DS, Newcomb DC, McMahon FB, Gleaves LA, Blackwell TS, Lawson WE. ß-catenin in the alveolar epithelium protects from lung fibrosis after intratracheal bleomycinAm. J. Respir. Crit. Care Med [print-electronic]. 2013 Mar 3/15/2013; 187(6): 630-9. PMID: 23306543, PMCID: PMC3733436, PII: rccm.201205-0972OC, DOI: 10.1164/rccm.201205-0972OC, ISSN: 1535-4970. 

Polosukhin VV, Degryse AL, Newcomb DC, Jones BR, Ware LB, Lee JW, Loyd JE, Blackwell TS, Lawson WE. Intratracheal bleomycin causes airway remodeling and airflow obstruction in miceExp. Lung Res. 2012 Apr; 38(3): 135-46. PMID: 22394287, PMCID: PMC4046254, DOI: 10.3109/01902148.2012.658595, ISSN: 1521-0499. 

Newcomb DC, Boswell MG, Huckabee MM, Goleniewska K, Dulek DE, Reiss S, Lukacs NW, Kolls JK, Peebles RS. IL-13 regulates Th17 secretion of IL-17A in an IL-10-dependent mannerJ. Immunol [print-electronic]. 2012 Feb 2/1/2012; 188(3): 1027-35. PMID: 22210911, PMCID: PMC3262924, PII: jimmunol.1102216, DOI: 10.4049/jimmunol.1102216, ISSN: 1550-6606. 

Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, Peebles RS. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitisPLoS ONE [print-electronic]. 2012; 7(5): e33518. PMID: 22590492, PMCID: PMC3349674, PII: PONE-D-10-03779, DOI: 10.1371/journal.pone.0033518, ISSN: 1932-6203. 

Boswell MG, Zhou W, Newcomb DC, Peebles RS. PGI2 as a regulator of CD4+ subset differentiation and functionProstaglandins Other Lipid Mediat [print-electronic]. 2011 Nov; 96(1-4): 21-6. PMID: 21864703, PMCID: PMC3215832, PII: S1098-8823(11)00073-6, DOI: 10.1016/j.prostaglandins.2011.08.003, ISSN: 1098-8823. 

Zhou W, Dowell DR, Geraci MW, Blackwell TS, Collins RD, Polosukhin VV, Lawson WE, Wu P, Sussan T, Biswal S, Goleniewska K, O'Neal J, Newcomb DC, Toki S, Morrow JD, Peebles RS. PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expressionAm. J. Physiol. Lung Cell Mol. Physiol [print-electronic]. 2011 Oct; 301(4): L615-22. PMID: 21764988, PMCID: PMC3774255, PII: ajplung.00224.2010, DOI: 10.1152/ajplung.00224.2010, ISSN: 1522-1504. 

Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, Xu XC, Newcomb DC, Jones BR, Roldan J, Lane KB, Morrisey EE, Beers MF, Yull FE, Blackwell TS. Endoplasmic reticulum stress enhances fibrotic remodeling in the lungsProc. Natl. Acad. Sci. U.S.A [print-electronic]. 2011 Jun 6/28/2011; 108(26): 10562-7. PMID: 21670280, PMCID: PMC3127925, PII: 1107559108, DOI: 10.1073/pnas.1107559108, ISSN: 1091-6490. 

Stokes KL, Chi MH, Sakamoto K, Newcomb DC, Currier MG, Huckabee MM, Lee S, Goleniewska K, Pretto C, Williams JV, Hotard A, Sherrill TP, Peebles RS, Moore ML. Differential pathogenesis of respiratory syncytial virus clinical isolates in BALB/c miceJ. Virol [print-electronic]. 2011 Jun; 85(12): 5782-93. PMID: 21471228, PMCID: PMC3126300, PII: JVI.01693-10, DOI: 10.1128/JVI.01693-10, ISSN: 1098-5514. 

Newcomb DC, Boswell MG, Zhou W, Huckabee MM, Goleniewska K, Sevin CM, Hershey GK, Kolls JK, Peebles RS. Human TH17 cells express a functional IL-13 receptor and IL-13 attenuates IL-17A productionJ. Allergy Clin. Immunol [print-electronic]. 2011 Apr; 127(4): 1006-13.e1. PMID: 21236478, PMCID: PMC3916096, PII: S0091-6749(10)01865-8, DOI: 10.1016/j.jaci.2010.11.043, ISSN: 1097-6825. 

Zaynagetdinov R, Ryzhov S, Goldstein AE, Yin H, Novitskiy SV, Goleniewska K, Polosukhin VV, Newcomb DC, Mitchell D, Morschl E, Zhou Y, Blackburn MR, Peebles RS, Biaggioni I, Feoktistov I. Attenuation of chronic pulmonary inflammation in A2B adenosine receptor knockout miceAm. J. Respir. Cell Mol. Biol [print-electronic]. 2010 May; 42(5): 564-71. PMID: 19556606, PMCID: PMC2874442, PII: 2008-0391OC, DOI: 10.1165/rcmb.2008-0391OC, ISSN: 1535-4989. 

Moore ML, Newcomb DC, Parekh VV, Van Kaer L, Collins RD, Zhou W, Goleniewska K, Chi MH, Mitchell D, Boyce JA, Durbin JE, Sturkie C, Peebles RS. STAT1 negatively regulates lung basophil IL-4 expression induced by respiratory syncytial virus infectionJ. Immunol [print-electronic]. 2009 Aug 8/1/2009; 183(3): 2016-26. PMID: 19587017, PMCID: PMC3755459, PII: jimmunol.0803167, DOI: 10.4049/jimmunol.0803167, ISSN: 1550-6606. 

Newcomb DC, Peebles RS. Bugs and asthma: a different disease?Proc Am Thorac Soc. 2009 May 5/1/2009; 6(3): 266-71. PMID: 19387028, PMCID: PMC2677401, PII: 6/3/266, DOI: 10.1513/pats.200806-056RM, ISSN: 1546-3222. 

Newcomb DC, Zhou W, Moore ML, Goleniewska K, Hershey GK, Kolls JK, Peebles RS. A functional IL-13 receptor is expressed on polarized murine CD4+ Th17 cells and IL-13 signaling attenuates Th17 cytokine productionJ. Immunol. 2009 May 5/1/2009; 182(9): 5317-21. PMID: 19380778, PMCID: PMC3711250, PII: 182/9/5317, DOI: 10.4049/jimmunol.0803868, ISSN: 1550-6606. 

Moore ML, Chi MH, Luongo C, Lukacs NW, Polosukhin VV, Huckabee MM, Newcomb DC, Buchholz UJ, Crowe JE, Goleniewska K, Williams JV, Collins PL, Peebles RS. A chimeric A2 strain of respiratory syncytial virus (RSV) with the fusion protein of RSV strain line 19 exhibits enhanced viral load, mucus, and airway dysfunctionJ. Virol [print-electronic]. 2009 May; 83(9): 4185-94. PMID: 19211758, PMCID: PMC2668460, PII: JVI.01853-08, DOI: 10.1128/JVI.01853-08, ISSN: 1098-5514. 

Zhou W, Newcomb DC, Moore ML, Goleniewska K, O'Neal JF, Peebles RS. Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responsesJ. Immunol. 2008 Oct 10/15/2008; 181(8): 5360-7. PMID: 18832692, PII: 181/8/5360, ISSN: 1550-6606.