Jonathan Brown, MD, is a cardiologist and basic scientist studying transcriptional mechanisms relevant to the pathogenesis of obesity, diabetes mellitus, and atherosclerosis. A central premise of his research involves a deeper understanding of the gene regulatory networks controlling disease pathogenesis to identify novel therapeutic targets to treat these prevalent and often fatal conditions.
Dr. Brown's research program focuses on the role of chromatin structure and chromatin-dependent signaling in cardiometabolic diseases including heart failure, atherosclerosis and metabolic disease associated with obesity. One theme focuses on how specific transcriptional coactivators drive pathologic gene expression in inflammation and fibrosis and how these programs can be disrupted with targeted small-molecule inhibitors. A second theme is examining aging and inflammation in the vasculature including in the genetic aging disease-Hutchinson-Gilford Progeria syndrome.
Ongoing work seeks to develop a deeper understanding of disease regulatory circuits through integration of epigenomic and transcriptomic analysis with the goal of discovering transcriptional regulators that drive cardiometabolic diseases.
Key Research Area
Genetics