Publications

The scientific influence of principal investigator Christopher Williams, scientific collaborators, and research personnel at the Williams Lab spans critical topics on intestinal epithelial repair programs. Below are highlights of our investigators’ featured contributions to high-impact publications. 

    Reactive oxygen species in intestinal disease


    • Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS. (2013) Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis. PLoS One; Jul 4;8(7):e67845. PMCID: PMC3701622.
    • Barrett CW, Ning W, Chen X, Smith JJ, Washington MK, Hill KE, Coburn LA, Peek RM, Chaturvedi R, Wilson KT, Burk RF, Williams CS. (2013) Tumor suppressor function of the plasma glutathione peroxidase gpx3 in colitis-associated carcinoma. Cancer Res, Feb 1;73(3):1245-55. PMCID: PMC3563732.
    • Barrett CW, Reddy VK, Short SP, Motley AK, Lintel MK, Bradley AM, Freeman T, Vallance J, Ning W, Parang B, Poindexter SV, Fingleton B, Chen X, Washington MK, Wilson KT, Shroyer NF, Hill KE, Burk RF, Williams CS. (2015) Selenoprotein P influences colitis-induced tumorigenesis by mediating stemness and oxidative damage. J Clin Invest, Jul 1;125(7):2646-60. PMCID: PMC4563672
    • Short SP, Pilat JM, Barrett CW, Reddy VK, Haberman Y, Hendren JR, Marsh BJ, Keating CE, Motley AK, Hill KE, Zemper AE, Washington MK, Shi C, Chen X, Wilson KT, Hyams JS, Denson LA, Burk RF, Rosen MJ, Williams CS, (2020) Colonic epithelial-derived Selenoprotein P is the source for antioxidant-mediated protection in colitis-associated cancer. Gastroenterology, Jan1; S0016-5085(20)35623-7. NIHMISD:1659519. PMC in Process.

    Junctional biology in epithelial barrier function


    • Williams CS, Zhang B, Smith JJ, Jayagopal A, Barrett CW, Pino C, Russ P, Presley SH, Peng D, Rosenblatt DO, Haselton FR, Yang JL, Washington MK, Chen X, Eschrich S, Yeatman TJ, El-Rifai W, Beauchamp RD, Chang MS. (2011) BVES regulates EMT in human corneal and colon cancer cells and is silenced via promoter methylation in human colorectal carcinoma. J Clin Invest, Oct 3;121(10):4056-69. PMCID: PMC3195453.
    • Reddy VK, Short SP, Barret CW, Harris E, Revetta F, Bader DM, Brand T, Washington MK, Williams CS. (2016) BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation. Stem Cells, Jun;34(6):1626-36. PMCID: PMC4893006.
    • Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta F, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS. (2017) BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumorigenesis. Gut, May;66(5):852-62. PMCID: PMC5385850.
    • Choksi YA, Reddy VK, Singh K, Barrett CW, Short SP, Parang B, Keating CM, Thompson JJ, Verriere TG, Piazuelo MB, Washington MK, Gobert AP, Coburn LA, Wilson KT, Williams CS (2018) “BVES Is Required for Maintenance of Colonic Epithelial Integrity in Experimental Colitis by Modifying Intestinal Permeability”, Mucosal Immunology, Sep;11(5):1363-1374. PMCID: PMC6162166.

    Epigenetic regulation of intestinal wound healing and inflammatory carcinogenesis


    • Barrett CW, Fingleton B, Williams A, Ning W, Fischer MA, Washington MK, Chaturvedi R, Wilson KT, Hiebert SW, Williams CS. MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis- associated carcinoma model. Cancer Res, 2011 Feb 15;71(4):1302-12. PubMed PMID: 21303973; PubMed Central PMCID: PMC3150168.
    • Williams CS, Bradley AM, Chaturvedi R, Singh K, Piazuelo MB, Chen X, McDonough EM, Schwartz DA, Brown CT, Allaman MM, Coburn LA, Horst SN, Beaulieu DB, Choksi YA, Washington MK, Williams AD, Fisher MA, Zinkel SS, Peek RM Jr, Wilson KT, Hiebert SW. (2013) MTG16 contributes to colonic epithelial integrity in experimental colitis. Gut, Oct;62(10):1446-55. PMCID: PMC3663894.
    • McDonough EM, Barrett CW, Parang B, Mittal MK, Smith JJ, Bradley AM, Choksi YA, Coburn LA, Short SP, Zhang B, Poindexter SV, Fischer MA, Chen X, Li J, Revetta FL, Naik R, Washington MK, Rosen MJ, Hiebert SW, Wilson KT, Williams CS. (2017) MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight, Aug 17;2(16):e78210. doi:10.1172/ jci.insight.78210. PMCID: PMC5621889.
    • Brown RE, Jacobse J, Anant SA, Blunt M, Chen B, Vega PN, Jones CT, Pilat JM, Revetta F, Gorby AM, Stengel KR, Choksi YA, Palin K, Piazuelo MB, Washington MK, Lau KS, Goettel JA, Hiebert SW, Short SP, and Williams CS. (2022) “MTG16 (CBFA2T3) represses E protein-dependent transcription to regulate colonic secretory cell differentiation, epithelial regeneration, and tumorigenesis”, JCI Insight, 2022 May 23;7(10):e153045. doi: 10.1172/jci.insight.153045. PMID: 35503250; PMCID: PMC9220854.