Research
The Huize Pan Lab focuses on mechanistic and translational research to understand how atherosclerosis progresses and to develop powerful approaches to prevent and treat the disease. We are also interested in uncovering the crosstalk between atherosclerotic cardiovascular disease and other diseases.
Direction 1. Pathogenesis of atherosclerosis
We use multidisciplinary approaches, including molecular and cellular biology, single-cell genomics, human genetics, mouse and human models, to investigate the molecular mechanisms of atherosclerosis development and progression.
Direction 2. Development of preventive and therapeutic strategies for atherosclerotic cardiovascular disease
We are dedicated to developing powerful tools and strategies, such as nanoparticles and gene transfer, to prevent atherosclerosis, induce disease regression, and stabilize disease plaques. Our goal is to facilitate their translation to clinical applications.
Direction 3. Interactions between atherosclerotic cardiovascular disease and other health conditions
We investigate the disease-disease crosstalk and interactions with the ultimate goals to deeply understand the pathogenesis of cardiovascular disease in the context of other healthy conditions/diseases.
