Welcome to the Mashayekhi Lab

We are a translational research group within the Division of Diabetes, Endocrinology and Metabolism in the Department of Medicine. We use mechanistic hypothesis-driven clinical studies to understand the basic physiology of obesity-associated inflammation and the impact of this inflammation on cardiovascular diseases.

Our current work centers on determining the immunologic effects of diabetes medications including SGLT2 inhibitors and GLP-1 receptor agonists, with the goal of uncovering how these treatments reduce inflammation and improve cardiovascular and metabolic health.

By studying immune cell function in clinical samples—including adipose tissue and peripheral blood—we aim to reveal new mechanisms through which these therapies confer benefits beyond glucose control and weight loss.