Quinn S. Wells, MD, PharmD, MSCI, is an Associate Professor of Medicine, Division of Cardiovascular Medicine, at Vanderbilt University Medical Center.
His research program is directed toward precision medicine for cardiovascular disease, with a special interest in cardiomyopathic phenotypes. The overarching goal of his lab is to understand how patient-specific features, including clinical and genetic factors, contribute to variable disease susceptibility and therapeutic response, and then translate this knowledge to patient-centered, precision care.
A major interest is leveraging the power of the electronic health record (EHR), and in 2014 he created and was appointed director of the Vanderbilt System for EHR-based Research in Cardiovascular Health (V-SERCH). V-SERCH is dedicated to developing for conducting research in the EHR environment, including advanced phenotyping methods incorporating machine learning, disease mechanism, and in vivo data.
Dr. Wells' group has led or contributed to multiple cardiovascular genomics efforts including exome sequencing-based Mendelian disease gene discovery, characterization of phenotypic variability in cardiometabolic disease, and studies of cardiovascular and drug toxicity phenotypes that have identified potentially novel risk loci. Methodologically, his group has developed natural language processing (NLP) tools to extract multiple high-value datatypes including ankle-brachial index (ABI) and echocardiographic parameters.