A recent paper from the Wanjalla lab, led by Dr. Laventa Obare and team, characterizes a population of CD3+ T cell–CD14+ monocyte complexes that are increased in people living with HIV (PLWH) and those with glucose intolerance.
These complexes form immune synapses, harbor more HIV, and are metabolically active. While cross-sectional, this study lays the groundwork for future longitudinal work using the CNICS cohort to understand complex-driven inflammation.
About CNICS: The CFAR Network of Integrated Clinical Systems (CNICS) provides rich, longitudinal data and biospecimens from PLWH across multiple clinical sites. Learn more at https://sites.uab.edu/cnics/