Bone Marrow Failure (myelodysplastic syndrome (MDS)
Leukemia and how inhibiting inflammation impacts disease
Genetically determined gene expression (PrediXcan, Gamazon et al., 2015) can be used to identify a subgroup of patients in BioVU with the lowest 5% of BID – our closest model to a “Bid-/-“ people. These individuals have a greater than 4-fold increased risk for myocardial infarction (MI).
The role of inflammatory cell death on the microenvironment and its impact on hematopoiesis, bone marrow failure, and leukemogenesis
The impact of genetically determined alterations in cell death pathways on susceptibility to human disease, using BioVU, in collaboration with Dr. Eric Gamazon.
