Dopamine Beta-Hydroxylase (DBH) Deficiency
What it is: A rare genetic condition where the body cannot make norepinephrine, a key chemical that helps control blood pressure.
What causes it: The body makes dopamine instead of norepinephrine, leading to poor blood pressure control.
Key Symptoms
- Very low blood pressure when standing (orthostatic hypotension).
- Dizziness, fainting, blurred vision.
- Drooping eyelids (ptosis).
- Fatigue and reduced ability to exercise.
Treatment
- Droxidopa (L-DOPS): Replaces missing norepinephrine and can significantly improve blood pressure.
- Other medications may help, but L-DOPS is most effective.