Understanding and monitoring drug-induced anaphylaxis

What is drug-induced anaphylaxis?

Medication, food, and other allergens can cause anaphylaxis, which is a serious allergic reaction that is rapid in onset and might cause death. The receipt of timely and targeted healthcare is essential for patients experiencing anaphylactic reactions. There is, unfortunately, limited knowledge of the ecological and genetic risk factors that predispose some patients to experience anaphylaxis and other individuals not to develop the condition, which impedes advancements in medical care.

About this study 

The objectives of this study are to contribute to the scientific knowledge of the environmental and immunogenetic risk factors that contribute to the susceptibility of experiencing anaphylaxis, assess whether and how long affected individuals remain at risk of symptoms, and understand the underlying cellular and molecular mechanisms that differentiate affected patients from individuals who are not at risk. To address these objectives, Dr. Cosby Stone, Jr., Dr. Elizabeth Phillips, and their research team are assessing both the genetic (human leukocyte antigens, HLA) and environmental risk factors that are critical to the development of true immunoglobulin E (IgE) mediated anaphylactic reactions. In addition, they are evaluating the duration and natural history of decreased anaphylactic risk among true IgE-mediated reactions. 

What is required of study participants?

The study staff ask participants to provide blood and saliva samples and undergo skin tests. Saliva samples can be collected without an accompanying blood draw when necessary. Kits designed for collecting saliva are mailed to participants with instructions on using them and shipping them back to the study site.  

If you are interested in this study, please complete a survey at the link below. A study team member will assess whether you meet the study criteria and contact you with additional information.

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More information

• This study is led by Cosby Stone, MD, MPH and co-investigated by Elizabeth Phillips, MD.
• For more information contact drugsafetyresearch@vumc.org