Crohn's Disease is a chronic inflammatory condition of the gastrointestinal tract affecting as many as 700,000 Americans, typically between the ages of 15 and 35. While the cause of Crohn's Disease is not well understood, recent research suggests hereditary, genetics, and/or environmental factors contribute to its development.

Crohn's disease causes inflammation in the lining of the digestive tract which can be very painful and sometimes debilitating. The symptoms of Crohn's disease vary from patient to patient in both presence and severity, but common symptoms include:

  • Abdominal cramping and pain
  • Persistent diarrhea
  • Rectal bleeding
  • Constipation
  • Fever
  • Nausea or loss of appetite
  • Fatigue
  • Weight loss

Since Crohn's is a chronic disease, patients usually experience flares with obvious symptoms followed by periods of remission when they may not notice any symptoms at all. If left untreated, Crohn's disease can lead to serious complications. 

Fortunately, there are several treatment options available for people living with Crohn's disease. While there is no known cure, these treatments work to reduce the signs and symptoms of the disease and introduce long-term remission. 

If you have not had success with available treatment options, search the clinical trials listed below and talk with your doctor about clinical trials you may be eligible for. Scientists and researchers are continually working to find ways to improve the quality of life for people living with Crohn's disease.

At Vanderbilt's GI Clinical Research Enterprise, we are dedicated to finding a solution that works for you.