Peebles Lab
The Peebles Lab, led by PI Stokes Peebles, MD, investigates mechanisms regulating lung inflammation, with specific emphasis on allergen-induced and virus-mediated disease.
Allergic airway inflammation is one of the most common diseases in both children and adults and is a strong predisposing factor for the development of asthma. Viral infections are causative in approximately 80% of children and 50% of adults.
Research in the Peebles Lab
Our lab has a particular interest in the interaction of allergic disease and respiratory syncytial virus in causing airways responsiveness. While we are interested in studying host immune responses to both allergens and viruses, we are particularly interested in the contribution of group 2 innate lymphoid cells (ILC2) as an initiator of lung inflammatory responses.
Additionally, our lab has a long-standing interest in how prostaglandins, particularly PGI2, regulate lung inflammatory responses. We have developed a variety of tools to understand how both endogenous and exogenous prostaglandin signaling modulates both allergen-induced and virus-induced pulmonary inflammation. We are now investigating how glucagon-like peptide-1 signaling regulates lung inflammation, as a possible treatment for asthma in the setting of obesity.
GLP-1R signaling inhibits innate immune allergic response.
RSV Infection in the Setting of STAT1 Deficiency Increases Mucus Metaplasia and Airways Responsiveness
Aberrant Type 2 Responses to RSV Results in Airway Mucus
ILC2 at the center of the allergy universe
PGE2 regulation of aspirin-exacerbated respiratory disease
RSV A2 infection induces gob5 expression in Stat1 -/- mice.
IL-33 expression in the lung as shown by citrine reporter
Life in the Peebles Lab
Grant Funding
Learn more about funded research projects in the Peebles Lab.
Contact us
Email Dr. Stokes Peebles for more information.