R01 AI 145265 (Peebles)
“PGI2 regulates Treg function”
Current Year Direct Cost: $315,060
This project will determine the mechanisms by which signaling through the prostaglandin (PG)I2 receptor promotes immune tolerance to aeroallergen-induced inflammation.
I01 BX 004299 (Peebles)
Merit Review Award
Department of Veterans Affairs
“PGI2 inhibition of pulmonary innate allergic immune responses”
Duration: 10/01/18 – 09/30/22
Current Year Direct Cost: $198,000
This project will determine the mechanisms by which PGI2 regulates IL-33 expression and release to inhaled allergen.
R01 AI 124456 (Peebles)
“GLP-1R Signaling in Allergic Inflammation”
Duration: 12/06/16 – 11/30/21
Current Year Direct Cost: $250,000
This project will determine the mechanisms by which signaling through the glucagon-like peptide-1 receptor (GLP-1R) inhibits both the early innate and later adaptive allergen-induced airway inflammatory responses. These proposed studies are clinically relevant in that GLP-1R agonists are currently FDA approved for the treatment of diabetes and obesity, and their use could possibly be extended to the treatment of allergic airway inflammatory diseases such as asthma.
U19 AI 095227 (Peebles)
“Host and Viral Determinants of Infant and Childhood Allergy and Asthma”
Duration: 08/01/16 – 07/31/21
Current Year Direct Cost: $1,082,276
RSV is the leading cause of bronchiolitis and causes >100,000 infant hospitalizations in the US each year. Studies have also revealed that severe RSV infection in infancy is associated with the later development of childhood asthma. This application will examine the effects of both host genetic and immune response determinants, as well as the influence of specific RSV strains on severity of RSV bronchiolitis and childhood asthma. The long-term objective of this proposed project is to define the relationship between infant respiratory syncytial virus (RSV) infection and the host response that enables asthma inception.
R21 AI 145397 (Peebles)
“Host genetics of allergen-induced lung TSLP expression and ILC2 function”
Duration: 06/01/19 – 05/31/21
Current Year Direct Cost: $150,000
The project will identify genetic determinants for allergen-induced TSLP expression and ILC2 activation using the Collaborative Cross mice.