Brian Lindman, MD, MSCI, is an Associate Professor of Medicine in the Division of Cardiovascular Medicine at Vanderbilt University Medical Center. His research is focused on calcific aortic stenosis, including clinical and translation studies related to biomarker discovery, risk prediction, and elucidating pathophysiology to identify adjunctive interventions to improve patient-centered outcomes.
He is actively involved in the VUMC heart valve team, evaluating patients clinically and performing echocardiograms for transcatheter valve procedures. His research group uses various imaging techniques and a biobank of specimens as they seek to identify novel targets and test pharmacologic therapies to improve clinical outcomes in patients with aortic stenosis. As a heart valve center, they seek to integrate a clinical and research mission in an innovative way that informs disease paradigms and influences management guidelines in valvular heart disease.
Dr. Lindman is a member of several writing groups for the American College of Cardiology (ACC), including the Appropriate Use Criteria for Aortic Stenosis and a clinical policy document on advanced valve centers. By participating in these national efforts, he seeks to play a role in shaping new systems of care for patients with valve disease that improve patient-centered outcomes. He is on the editorial boards for leading cardiovascular journals, including JACC and Circulation, and actively publishes original research manuscripts in these and other journals.
He has been the recipient of numerous government, foundation, and industry grants, including an NIH K23 Career Development Award and a Doris Duke Clinical Scientist Development Award.
Key Research Areas
Cardiac Rehab
Cardiovascular Imaging
Valvular/Structural Heart Disease
Grants
- 2023-2027, NHLBI, Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis
- 2023-2024, NHLBI, Circulating Proteomics to Phenotype the Development and Reversal of Myocardial Remodeling in Aortic Stenosis (administrative supplement)
- 2022-2027, NIA, Home-based cardiac rehabilitation using a novel mobile health exercise regimen following transcatheter heart valve interventions (HOME RUN HITTER)
- 2021-2029, Edwards Lifesciences, PROGRESS biobank
- 2017-2024, Edwards Lifesciences, EARLY TAVR biobank
Honors and Awards
- 2023: Writing group member, ACC Appropriate Use Criteria (AUC) for Severe Aortic Stenosis
- 2022: Outstanding Contributions to Resident Research Mentorship Award, Vanderbilt University Medical Center Department of Medicine
- 2021: Chair, national ACC initiative "Improving Diagnosis of Aortic Stenosis"
- 2021: Writing Group Lead - The Heart Valve Collaboratory is spearheading an initiative to fast-track clinical trials testing medical therapy to slow progression of calcific aortic valve disease; this effort includes international leaders in aortic stenosis and leaders from NHLBI and FDA to develop a roadmap for progress (Lindman et al. Evaluating Medical Therapy for Calcific Aortic Stenosis: JACC State-of-the-Art Review 2021)
- 2019: NHLBI Working Group on Patient-Centered Research in Valvular Heart Disease (group member and lead author of the report - Lindman et al. J Am Heart Assoc. 2020;9:e015975)
- 2017-2019: Writing group member, multi-society expert consensus systems of care document - A Proposal to Optimize Care for Patients with Valvular Heart Disease (Nishimura et al. JACC 2019;73:2609-35).
- 2016-2020: Editorial Team Lead, Valvular Heart Disease Section - ACC.org
- 2015-2017: Writing group member, ACC Appropriate Use Criteria (AUC) for Severe Aortic Stenosis (Bonow et al. JACC 2017;70:2566-98)
- Editorial Board member: Journal of the American College of Cardiology (2014- ), Circulation (2016- ), Circulation Cardiovascular Imaging (2018- )
- 2014-18 Doris Duke Clinical Scientist Development Award Recipient
- 2013 Jeremiah Stamler Distinguished Young Investigator Research Award, Northwestern Cardiovascular Young Investigators' Forum
- 2013-2016 NIH K23 Career Development Award Recipient
- 2012-2014 Award Recipient, Gilead Sciences Research Scholars Program in Cardiovascular Disease
- 2010-2013 KL2 Scholar, Clinical Research Training Center, Institute for Clinical and Translational Sciences, Washington University in St. Louis