Vanderbilt Pulmonary Fibrosis Research Group

Research Focus

The Pulmonary Fibrosis Research group at Vanderbilt is a multidisciplinary team focused on improving treatment for patients with idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases.

The Vanderbilt Idiopathic Pulmonary Fibrosis Center is an internationally recognized center of excellence for patient care, education, clinical trials, and lung transplantation.

The Vanderbilt Pulmonary Fibrosis Research Group has a longstanding program working with patients who have familial or inherited forms of pulmonary fibrosis, a syndrome known as Familial Interstitial Pneumonia or FIP. These studies have provided crucial insights into the genetic causes of pulmonary fibrosis and molecular mechanisms of disease.

Current areas of research include:

  • Identifying genetic causes of pulmonary fibrosis in families
  • Improving methods for early detection of pulmonary fibrosis
  • Molecular mechanisms of telomerase mutations
  • Endoplasmic reticulum stress and lung epithelial cell dysfunction
  • Viral infection and adaptive immunity in pulmonary fibrosis
  • Rare lung diseases
  • Single-cell genomics of pulmonary fibrosis

Enrollment in clinical research studies is ongoing.