Molecular Endocrinology Training Program (METP)

METP Overview

 

The METP is a combined pre-doctoral and post-doctoral program that trains individuals for careers in molecular endocrinology-related research. 

Molecular endocrinology includes ligand-receptor interactions, signal generation and transduction, the molecular actions of intracellular signals, and the cellular and physiological consequences of hormone action. 

Vanderbilt has a long tradition of excellent research in these areas and career outcomes for participants in the METP program are strong.


METP at a glance


Program Director: 
Richard O'Brien, PhD

Established: 1988

Size: 12 total; 8 PhD students, 4 postdocs

T32

PhD students, Postdocs

Application materials can be emailed to Dana Doss

The Vanderbilt METP has a highly successful track record

 

More than 200 pre- and postdoctoral trainees have been supported by the METP over the years and have gone on to pursue rewarding careers in molecular endocrinology-related research. Program alumni work in academic positions, biotech/pharmaceutical industries, hold technical positions in research laboratories, pursue clinical practice, teach, go into business, or work as science writers, government researchers, university administrators, or as non-governmental science or health agency staff.

The field of molecular endocrinology is clearly of central relevance to multiple human diseases, most notably obesity and diabetes. Continued progress towards understanding and curing these and many other diseases requires that the next generation of scientists be given the knowledge and skills to perform independent research. Providing this training is the goal of the METP.

METP Program History and Outcomes

 

History

The Molecular Endocrinology Training Program began in 1988 and is now in its 38th year of NIDDK funding. It was directed by Dr. Daryl Granner from 1988-2004 and has been directed by Dr. Richard O’Brien since 2004. 

The program builds on Vanderbilt's leadership in the field, where some of the important fundamental concepts were established: cAMP as a second messenger, Earl Sutherland (pictured in portrait); growth factor receptors as tyrosine kinases, Stanley Cohen; the regulation of glucose uptake by insulin, C.R. Park and Tetsuro Kono. Sutherland and Cohen both won the Nobel Prize in Physiology or Medicine for their discoveries.

Outcomes

Of the 146 pre-doctoral trainees that have been supported by the METP over the duration of the program, 22 are still in pre-doctoral training. Of the remaining 124 individuals, 96 graduated with a PhD, 15 graduated with a master’s degree, 10 left with no degree and three received supplemental support from the NIDDK Medical Student Research Training (MSRT) program during their training as MDs.

Of those who graduated with a PhD degree, 35 are pursuing careers that primarily involve bench research and 10 are in careers involving research administration. Some of our predoctoral trainees make significant contributions in other science-related fields, such science writing (5/96), or as faculty in university science departments with a primary focus on teaching rather than research (10/96), or as high school science teachers (5/96) or MDs in clinical medicine (7/96) and 12 have moved onto post-doctoral training. Seven of these individuals now have careers in business. 

The career outcomes data are remarkably similar for the 72 postdoctoral trainees that have been supported by the METP over the duration of the program. Thirty-two of 72 are pursuing careers that primarily involve bench research and 12/72 are in careers involving research administration. Some of our postdoctoral trainees make significant contributions in other science-related fields, such science writing (3/72) or as faculty in university science departments with a primary focus on teaching rather than research (3/72), or as high school science teachers (1/72) or MDs in clinical medicine (3/72) and another 11/72 are still in training. Three of these 72 individuals now have careers in business. 

Unique Features of the METP

Collaborative training environment

A key feature of the METP, and Vanderbilt as a whole, is the fact that faculty preceptors are extremely interactive and scientific collaborations are common, often involving graduate students and post-doctoral trainees. Several weekly data clubs exist, involving multiple METP preceptors and trainees, which foster interactions between trainees and preceptors and provide trainees with a valuable opportunity to present, and obtain feedback on, their research data. These data clubs include the Beta Cell Interest Group and the Metabolism Interest Group.

Mouse Metabolic Phenotyping Center

The training experience available to METP trainees is enriched by the presence of the NIDDK-funded Vanderbilt Diabetes Research and Training Center. This not only funds an excellent seminar series but also numerous core facilities that provide molecular biology reagents, assays (hormones & metabolites), imaging facilities, isolated islets, and assistance with the development of knock-out and/or transgenic mice. Many trainees benefit from assistance by the NIDDK-funded Mouse Metabolic Phenotyping Center (MMPC), a unique resource that supports cutting edge metabolic research in mice. 

Clinical and Research Pathways

Pre- and post-doctoral trainees who are interested in coupling basic science research with clinical problems have the option to enroll in the ASPIRE Path in Molecular Medicine. This innovative program provides a personalized approach that aims to train a new generation of PhD biomedical researchers with the skills necessary for understanding and developing breakthroughs in clinical research fields. 

Post-doctoral trainees considering a career in patient-oriented research also have the option to enroll in the Master of Science in Clinical Investigation Program at Vanderbilt. 

Vanderbilt Summer Science Academy

The METP receives multiple applications seeking support each year but to further increase the pre-doctoral applicant pool we established the Vanderbilt Summer Diabetes Research Program(VSDRP). The VSDRP is one of the programs integrated into the Vanderbilt Summer Science Academy (VSSA), an umbrella program that arranges on-campus housing and represents an efficient mechanism for provide training in RCR as well as radiation, chemical and biosafety. The VSSA also organizes multiple enrichment sessions relating to graduate school applications and careers in the biosciences. Finally, through the Summer Science Symposium, at which trainees present their research, and the various social events it organizes, the VSSA also provides trainees with the opportunity to meet and discuss their science with individuals in other summer research programs. 

The VSDRP is funded entirely by the Vanderbilt Diabetes Center and provides a 9-week summer diabetes research experience for undergraduates following their junior or sophomore years. We anticipate that VSDRP trainees will subsequently apply to the Vanderbilt IGP or QCB programs and then join the METP. To foster a connection between VSDRP trainees and the METP they are assigned a METP trainee to act as a mentor during their 9 week stay at Vanderbilt.


METP 2026 Applicant Information and Program Requirements


Program Director:
Richard M. O’Brien, PhD
Professor of Molecular Physiology & Biophysics
Director of Graduate Studies for Molecular Physiology & Biophysics 
Coordinator of the DRTC Research Base

 

Program Associate Director:
Julio Ayala, PhD
Associate Professor of Molecular Physiology & Biophysics

 

Program Contact:
Dana Doss

The METP is composed of 29 faculty members from five basic science departments. Of this group, 24 are tenured faculty with stable, well-funded programs and extensive training experience and five are new investigators. The preceptor group constitutes an unusually talented group of individuals whose work covers the spectrum of molecular endocrinology. 

These preceptors conduct research in the general areas of:

  1. Signal transduction
  2. Metabolic regulation
  3. Islet cell development and function

Faculty

Primary Appointment

Rafael Arrojo e Drigo, PhD VUSM Department of Molecular Physiology and Biophysics
Julio Ayala, PhD VUSM Department of Molecular Physiology and Biophysics
Ray Blind, PhD Division of Diabetes, Endocrinology and Metabolism, Department of Medicine
Mark Boothby, MD, PhD Department of Pathology, Microbiology and Immunology
Mariana Byndloss, PhD, DVM Department of Pathology, Microbiology and Immunology
Nancy Carrasco, MD VUSM Department of Molecular Physiology and Biophysics
Bruce Carter, PhD VUCM Department of Biochemistry
Jeeyeon Cha, MD, PhD Division of Diabetes, Endocrinology and Metabolism, Department of Medicine
Wenbiao Chen, PhD VUSM Department of Molecular Physiology & Biophysics
Alan Cherrington, PhD VUSM Department of Molecular Physiology & Biophysics
Derek Claxton, PhD VUSM Department of Molecular Physiology & Biophysics
Katie Coate, PhD VUSM Department of Molecular Physiology and Biophysics
Roger Colbran, PhD VUSM Department of Molecular Physiology and Biophysics
Danielle (Erika) Dean, PhD Division of Diabetes, Endocrinology and Metabolism, Department of Medicine
Maureen Gannon, PhD Division of Diabetes, Endocrinology and Metabolism, Department of Medicine
Heidi Hamm, PhD VU Department of Pharmacology
AJ Hinton, PhD VUSM Department of Molecular Physiology and Biophysics
David Jacobson, PhD VUSM Department of Molecular Physiology and Biophysics
Erkan Karakas, PhD VUSM Department of Molecular Physiology and Biophysics
Irina Kaverina, PhD VUSM Department of Cell and Developmental Biology
Ethan Lee, MD, PhD VUSM Department of Cell and Developmental Biology
Mark Magnuson, MD VUSM Department of Molecular Physiology and Biophysics
Doug Mitchell, PhD VUSM Department of Biochemistry
Richard O’Brien, PhD VUSM Department of Molecular Physiology and Biophysics
Al Powers, MD Division of Diabetes, Endocrinology and Metabolism, Department of Medicine
Richard Simerly, PhD VUSM Department of Molecular Physiology and Biophysics
Roland Stein, PhD VUSM Department of Molecular Physiology and Biophysics
Brian Wadzinski, PhD VU Department of Pharmacology
Elma Zaganjor, PhD VUSM Department of Molecular Physiology and Biophysics

Predoctoral

Nickles, G

Peachee, S

Reynolds, G 

Volmer, H

07/01/24-06/30/25

Postdoctoral

  • Chang-Gonzalez, A.
  • Schleh, M.
  • Simke, W.
  • Chapagain, P.

Predoctoral

  • DelBene, A.
  • Gibson, S.
  • Schnornack, A.
  • Silvestri, I.
  • Buzzelli, L.
  • Harris, S.
  • Haynes, A.
  • Mohanty, N.

07/01/23-06/30/24

Postdoctoral

  • Chang-Gonzalez, A.
  • Schleh, M.
  • Carroll (Thomas), D.
  • Chapagain, P.

Predoctoral

  • Acree, C.
  • Besing, G-L.
  • Garcia, M.
  • Wokasch, A.
  • DelBene, A.
  • Gibson, S.
  • Schnornack, A.
  • Silvestri, I.

07/01/22-06/30/23

Postdoctoral

  • Garcia, J.
  • Deaver, JW.
  • (Pinckard) Schaefers, K.
  • Vue, Z.

Predoctoral

  • Crabtree, A
  • Dobson, J
  • Raghavan, R
  • Waterman, H
  • Acree, C
  • Besing, G-L
  • Garcia, M
  • Wokasch, A

07/01/21-06/30/22

Postdoctoral

  • Garcia, J.
  • Deaver, JW.
  • (Pinckard) Schaefers, K.
  • Vue, Z.

Predoctoral

  • Burkett, J.
  • Fye, M.
  • McDaniel, J.
  • Quay, J.
  • Crabtree, A.
  • Dobson, J.
  • Raghavan, R.
  • Waterman, H.

07/01/20-06/30/21

Postdoctoral

  • Morrison, V.
  • Turkewitz, D.
  • Stivison, E.
  • Schaub, C.

Predoctoral

  • Covington, B.
  • Overway, E.
  • Stanley, J.
  • Carroll (Thomas), D.
  • Burkett, J.
  • Fye, M.
  • McDaniel, J.
  • Quay, J.

07/01/19-06/30/20

Postdoctoral

  • Morrison, V.
  • Able, A.
  • Stivison, E.
  • Schaub, C.

Predoctoral

  • Stauffer, P.
  • Norris, A.
  • Sweet, S.
  • Volk, K.
  • Covington, B.
  • Overway, E.
  • Stanley, J.
  • Carroll (Thomas), D.

07/01/18-06/30/19

Postdoctoral

  • Bales, M.
  • Caslin-Findley, H.
  • Winn, N.
  • Bedenbaugh, M.

Predoctoral

  • Jordan, K.
  • Christensen, A.
  • Fathi, P.
  • Mendoza-Romero, H.
  • Stauffer, P.
  • Norris, A.
  • Sweet, S.
  • Volk, K.

07/01/17-06/30/18

Postdoctoral

  • Jaramillo, A.
  • McClatchey, P.M.
  • Bales, M
  • Caslin-Findley, H

Predoctoral

  • Bryant, J.
  • Cottam, M.
  • Townsend, S.
  • Jordan, K.
  • Christensen, A.
  • Fathi, P.
  • Mendoza-Romero, H.
  • Richardson, T.

07/01/16-06/30/17

Postdoctoral

  • Altman, M.
  • Neuman, J.
  • Jaramillo, A.
  • McClatchey, P.M.

Predoctoral

  • Graff (Milian), S.
  • Perreault, A.
  • Seacrist, C.
  • Shumate, K.
  • Bryant, J.
  • Cottam, M.
  • Goleva, S.
  • Townsend, S.

07/01/15-06/30/16

Postdoctoral

  • Beck, T.
  • Hutchinson-Feigerle, K.
  • Altman, M.
  • Neuman, J.

Predoctoral

  • Bosma, K.
  • Dudek, K.
  • Gibbons, H.
  • Trefts, E.
  • Graff (Milian), S.
  • Perreault, A.
  • Seacrist, C.
  • Shumate, K.

07/01/14-06/30/15

Postdoctoral

  • Cyphert, T.
  • Simone Hyde, A.
  • Beck, T.
  • Hutchinson-Feigerle, K.

Predoctoral

  • Perfitt, T.
  • Vierra, N.
  • Sprunger (Walheim), D
  • Williams, I.
  • Bosma, K.
  • Dudek, K.
  • Gibbons, H.
  • Trefts, E.

The Molecular Endocrinology Training Program (METP) is supported by NIH grant T32 DK07563 and by the Vanderbilt Diabetes Research Center (NIH grant DK20593).

Questions? Contact Us


Molecular Endocrinology Training Program (METP) 

Vanderbilt University Medical Center
Nashville, TN 37232 

richard.obrien@vanderbilt.edu

dana.i.doss@vanderbilt.edu