Publications

J Am Heart Assoc. 2026 May 5;15(9):e043186. doi: 10.1161/JAHA.125.043186. Epub 2026 Apr 20. "Plasma von Willebrand Factor and ADAMTS13 Interact With APOE-ε4 in Predicting Longitudinal Brain Atrophy and Cognitive Decline Over a 9-Year Follow-Up." Adegboye HA, Sun Y, Zhang P, Liu D, Khan OA, Tanriverdi K, Risitano A, Libby J, Patterson KL, Arul AB, Oliver NC, Whitaker MD, Janve VA, Dumitrescu LC, Pechman KR, Shashikumar N, Bolton CJ, Davis LT, Landman BA, Freedman JE, Robinson RAS, Hohman TJ, Jefferson AL.
medRxiv [Preprint]. 2026 Feb 17:2026.02.12.26346203. doi: 10.64898/2026.02.12.26346203. "A multi-layered approach to elucidate mechanisms of physical function in response to rehabilitation in heart failure with preserved ejection fraction." Perry AS, O'Connor C, Pavicic M, Sheng Q, Farber-Eger E, Sarkar A, Lin P, Evans P, Tanriverdi K, Risitano A, Peters AE, Chen H, Upadhya B, Whellan DJ, Pastva A, Mentz RJ, Bertoni A, Semelka C, Brubaker PH, Molina AJA, Newland R, Nelson B, Lane M, Sullivan KA, Townsend A, Vlot A, Nsoh B, Allen PD, Wells Q, Reeves GR, Jacobson D, Kitzman DW, Gamazon ER, Nayor M, Shah RV.
Coron Artery Dis. 2026 Jun 1;37(4):271-279. doi: 10.1097/MCA.0000000000001593. Epub 2025 Nov 19. "Matrix metalloproteinase-1 and interleukin-17A are associated with previous plaque disruption: a combined proteomics and optical coherence tomography study." Covani M, Niccoli G, Niida T, Minami Y, Scalamera R, Fujimoto D, Nakamura S, Nakajima A, Tanriverdi K, Vergallo R, Porto I, McNulty I, Lee H, Yonetsu T, Jang IK.
J Am Heart Assoc. 2025 May 20;14(10):e037100. doi: 10.1161/JAHA.124.037100. Epub 2025 May 15. "Circulating Proteomics Identifies a Dynamic Profile of Hepatic Steatosis During Metabolic Intervention." El-Sabawi B, Tanriverdi K, Gajjar P, Nayor M, Landman JM, Below JE, Haff M, Long M, Ezpeleta M, Freedman JE, Varady K, Shah R, Perry AS.
Cell Rep Med. 2024 Dec 17;5(12):101871. doi: 10.1016/j.xcrm.2024.101871. Epub 2024 Dec 9. "A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver." Perry AS, Hadad N, Chatterjee E, Jimenez-Ramos M, Farber-Eger E, Roshani R, Stolze LK, Betti MJ, Zhao S, Huang S, Martens L, Kendall TJ, Thone T, Amancherla K, Bailin S, Gabriel CL, Koethe J, Carr JJ, Terry JG, Vaitinadin NS, Freedman JE, Tanriverdi K, Alsop E, Van Keuren-Jensen K, Sauld JFK, Mahajan G, Khan SS, Colangelo L, Nayor M, Fisher-Hoch S, McCormick JB, North KE, Below JE, Wells QS, Abel ED, Kalhan R, Scott C, Guilliams M, Gamazon ER, Fallowfield JA, Banovich NE, Das S, Shah R.
Proteomics. 2024 Aug;24(16):e2300607. doi: 10.1002/pmic.202300607. Epub 2024 May 24. "Capillary blood self-collection for high-throughput proteomics." El-Sabawi B, Huang S, Tanriverdi K, Perry AS, Amancherla K, Jackson N, Hulsey J, Freedman JE, Shah R, Lindman BR.
Arterioscler Thromb Vasc Biol. 2024 Apr;44(4):969-975. doi: 10.1161/ATVBAHA.124.320737. Epub 2024. "Differences in Cardiometabolic Proteins in Pregnancy Prioritize Relevant Targets of Preeclampsia." Lindley KJ, Perry A, Jacobs M, Petty L, Amancherla K, Zhao S, Barker C, Davila-Roman VG, Khan SS, Osmundson SS, Tanriverdi K, Freedman JE, Below J, Shah RV, Laurent LC.
medRxiv [Preprint]. 2024 Jan 29:2024.01.26.24301828. doi: 10.1101/2024.01.26.24301828. Update in: Cell Rep Med. 2024 Dec 17;5(12):101871. "A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver." Perry AS, Hadad N, Chatterjee E, Ramos MJ, Farber-Eger E, Roshani R, Stolze LK, Zhao S, Martens L, Kendall TJ, Thone T, Amancherla K, Bailin S, Gabriel CL, Koethe J, Carr JJ, Terry JG, Freedman J, Tanriverdi K, Alsop E, Keuren-Jensen KV, Sauld JFK, Mahajan G, Khan S, Colangelo L, Nayor M, Fisher-Hoch S, McCormick J, North KE, Below J, Wells Q, Abel D, Kalhan R, Scott C, Guilliams M, Fallowfield JA, Banovich NE, Das S, Shah R.
Circ Genom Precis Med. 2024 Feb;17(1):e004192. doi: 10.1161/CIRCGEN.123.004192. Epub 2024 Feb 7. "Targeted Proteomics Reveals Functional Targets for Early Diabetes Susceptibility in Young Adults." Shah RV, Zhong J, Massier L, Tanriverdi K, Hwang SJ, Haessler J, Nayor M, Zhao S, Perry AS, Wilkins JT, Shadyab AH, Manson JE, Martin L, Levy D, Kooperberg C, Freedman JE, Rydén M, Murthy VL.
J Thromb Thrombolysis. 2024 Feb;57(2):204-211. doi: 10.1007/s11239-023-02938-z. Epub 2024 Jan 31. "Proteomics associated with coronary high-risk plaques by optical coherence tomography." Niida T, Yuki H, Suzuki K, Kinoshita D, Fujimoto D, Nakajima A, McNulty I, Lee H, Tanriverdi K, Nakamura S, Jang IK.
J Am Heart Assoc. 2023 Nov 7;12(21):e029980. doi: 10.1161/JAHA.122.029980. Epub 2023 Oct 27. "Proteomics and Precise Exercise Phenotypes in Heart Failure With Preserved Ejection Fraction: A Pilot Study." Shah RV, Hwang SJ, Murthy VL, Zhao S, Tanriverdi K, Gajjar P, Duarte K, Schoenike M, Farrell R, Brooks LC, Gopal DM, Ho JE, Girerd N, Vasan RS, Levy D, Freedman JE, Lewis GD, Nayor M.
Obesity (Silver Spring). 2023 Jan;31(1):150-158. doi: 10.1002/oby.23587. Epub 2022 Nov 5. "The inflammatory proteome, obesity, and medical weight loss and regain in humans." Perry AS, Tanriverdi K, Risitano A, Hwang SJ, Murthy VL, Nayor M, Zhao S, Levy D, Shah RV, Freedman JE.
Arterioscler Thromb Vasc Biol. 2021 Feb;41(2):854-864. doi: 10.1161/ATVBAHA.120.315186. Epub 2020 Dec 10. PMID: 33297754. "The Dynamic Platelet Transcriptome in Obesity and Weight Loss." Ezzaty Mirhashemi M, Shah RV, Kitchen RR, Rong J, Spahillari A, Pico AR, Vitseva O, Levy D, Demarco D, Shah S, Iafrati MD, Larson MG, Tanriverdi K, Freedman JE.
J Surg Res. 2020 Aug 25;257:203-212. doi: 10.1016/j.jss.2020.06.027. "A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears." Fazzalari A, Basadonna G, Kucukural A, Tanriverdi K, Koupenova M, Pozzi N, Kakuturu J, Friedrich AU, Korstanje R, Fowler N, Belant JL, Beyer DE Jr, Brooks MB, Dickson EW, Blackwood M, Mueller C, Palesty JA, Freedman JE, Cahan MA.
PLoS One. 2020 Aug 19;15(8):e0236960. doi: 10.1371/journal.pone.0236960. PMID: 32813736; PMCID: PMC7437902. "Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study." Vaze A, Tran KV, Tanriverdi K, Sardana M, Lessard D, Donahue JK, Barton B, Aurigemma G, Lubitz SA, Lin H, Nasr GH, Mandapati A, Benjamin EJ, Vasan RS, Freedman JE, McManus DD.
AIDS. 2019 Dec 1;33(15):2351-2361. doi: 10.1097/QAD.0000000000002368. PMID: 31764100; PMCID: PMC6905123. "MicroRNA biomarkers associated with type 1 myocardial infarction in HIV-positive individuals." Yuan N, Scherzer R, Tanriverdi K, Martin J, Rahalkar S, Hsue P.
J Clin Transl Res. 2019 Jun 8;5(1):33-43. PMID: 31579840; PMCID: PMC6765153. "Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome." Tran KV, Tanriverdi K, Aurigemma GP, Lessard D, Sardana M, Parker M, Shaikh A, Gottbrecht M, Milstone Z, Tanriverdi S, Vitseva O, Keaney JF, Kiefe CI, McManus DD, Freedman JE.
iScience. 2019 Sep 27;19:916-926. doi: 10.1016/j.isci.2019.08.035. Epub 2019 Aug 24. PMID: 31518900; PMCID: PMC6742912. "Pollen-derived RNAs Are Found in the Human Circulation." Koupenova M, Mick E, Corkrey HA, Singh A, Tanriverdi SE, Vitseva O, Levy D, Keeler AM, Ezzaty Mirhashemi M, ElMallah MK, Gerstein M, Rozowsky J, Tanriverdi K, Freedman JE.
Front Cardiovasc Med. 2019 Aug 14;6:115. doi: 10.3389/fcvm.2019.00115. PMID: 31475159; PMCID: PMC6702296. "Micro-RNAs Are Related to Epicardial Adipose Tissue in Participants With Atrial Fibrillation: Data From the MiRhythm Study." Tran KV, Majka J, Sanghai S, Sardana M, Lessard D, Milstone Z, Tanriverdi K, Freedman JE, Fitzgibbons TP, McManus D.
Epigenetics. 2020 Jan-Feb;15(1-2):183-198. doi: 10.1080/15592294.2019.1640547. Epub 2019 Jul 17. PMID: 31282290; PMCID: PMC6961684. "Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits." Huan T, Mendelson M, Joehanes R, Yao C, Liu C, Song C, Bhattacharya A, Rong J, Tanriverdi K, Keefe J, Murabito JM, Courchesne P, Larson MG, Freedman JE, Levy D.
BMC Cancer. 2019 May 10;19(1):436. doi: 10.1186/s12885-019-5636-y. PMID: 31077182; PMCID: PMC6511137. "Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer." McAnena P, Tanriverdi K, Curran C, Gilligan K, Freedman JE, Brown JAL, Kerin MJ.
Cell. 2019 Apr 4;177(2):231-242. doi: 10.1016/j.cell.2019.03.023. PMID: 30951667; PMCID: PMC6601620. "The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research." Das S; Extracellular RNA Communication Consortium, Ansel KM, Bitzer M, Breakefield XO, Charest A, Galas DJ, Gerstein MB, Gupta M, Milosavljevic A, McManus MT, Patel T, Raffai RL, Rozowsky J, Roth ME, Saugstad JA, Van Keuren-Jensen K, Weaver AM, Laurent LC.
Arterioscler Thromb Vasc Biol. 2019 Jan;39(1):107-115. doi: 10.1161/ATVBAHA.118.311928. PMID: 30580566; PMCID: PMC6309981. "Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community." Shah RV, Hwang SJ, Yeri A, Tanriverdi K, Pico AR, Yao C, Murthy V, Ho J, Vitseva O, Demarco D, Shah S, Iafrati MD, Levy D, Freedman JE.
J Acquir Immune Defic Syndr. 2018 Dec 15;79(5):644-650. "Unique Circulating MicroRNA Profiles in HIV Infection." Narla V, Bhakta N, Freedman JE, Tanriverdi K, Maka K, Deeks SG, Ganz P, Hsue P.
JAMA Cardiol. 2018 Sep 1;3(9):871-876. "Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure." Shah RV, Rong J, Larson MG, Yeri A, Ziegler O, Tanriverdi K, Murthy V, Liu X, Xiao C, Pico AR, Huan T, Levy D, Lewis GD, Rosenzweig A, Vasan RS, Das S, Freedman JE.
EBioMedicine. 2018 Jun;32:172-181. "Plasma Circulating Extracellular RNAs in Left Ventricular Remodeling Post-Myocardial Infarction." Danielson KM, Shah R, Yeri A, Liu X, Camacho Garcia F, Silverman M, Tanriverdi K, Das A, Xiao C, Jerosch-Herold M, Heydari B, Abbasi S, Van Keuren-Jensen K, Freedman JE, Wang YE, Rosenzweig A, Kwong RY, Das S.
Sci Rep. 2018 Apr 23;8(1):6397. "Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population." Koupenova M, Mick E, Corkrey HA, Huan T, Clancy L, Shah R, Benjamin EJ, Levy D, Kurt-Jones EA, Tanriverdi K, Freedman JE.
Aging Cell. 2018 Feb;17(1). "Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits." Huan T, Chen G, Liu C, Bhattacharya A, Rong J, Chen BH, Seshadri S, Tanriverdi K, Freedman JE, Larson MG, Murabito JM, Levy D.
Circ Cardiovasc Genet. 2017 Oct;10(5). "MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage." Willinger CM, Rong J, Tanriverdi K, Courchesne PL, Huan T, Wasserman GA, Lin H, Dupuis J, Joehanes R, Jones MR, Chen G, Benjamin EJ, O'Connor GT, Mizgerd JP, Freedman JE, Larson MG, Levy D.
Aging Cell. 2017 Aug;16(4):888-894. "Cross-sectional relations of whole-blood miRNA expression levels and hand grip strength in a community sample." Murabito JM, Rong J, Lunetta KL, Huan T, Lin H, Zhao Q, Freedman JE, Tanriverdi K, Levy D, Larson MG.
Stroke. 2017 Apr;48(4):828-834. "Stroke and Circulating Extracellular RNAs." Mick E, Shah R, Tanriverdi K, Murthy V, Gerstein M, Rozowsky J, Kitchen R, Larson MG, Levy D, Freedman JE.
Diabetes Care. 2017 Apr;40(4):546-553. "Extracellular RNAs Are Associated with Insulin Resistance and Metabolic Phenotypes." Shah R, Murthy V, Pacold M, Danielson K, Tanriverdi K, Larson MG, Hanspers K, Pico A, Mick E, Reis J, de Ferranti S, Freinkman E, Levy D, Hoffmann U, Osganian S, Das S, Freedman JE.
BMC Genomics. 2017 Feb 8;18(1):139. "Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors." McManus DD, Rong J, Huan T, Lacey S, Tanriverdi K, Munson PJ, Larson MG, Joehanes R, Murthy V, Shah R, Freedman JE, Levy D.
Genome Biol. 2017 Jan 25;18(1):16. "Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies." Joehanes R, Zhang X, Huan T, Yao C, Ying SX, Nguyen QT, Demirkale CY, Feolo ML, Sharopova NR, Sturcke A, Schäffer AA, Heard-Costa N, Chen H, Liu PC, Wang R, Woodhouse KA, Tanriverdi K, Freedman JE, Raghavachari N, Dupuis J, Johnson AD, O'Donnell CJ, Levy D, Munson PJ.
PLoS One. 2016 Apr 28;11(4):e0153691. "Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources." Shah R, Tanriverdi K, Levy D, Larson M, Gerstein M, Mick E, Rozowsky J, Kitchen R, Murthy V, Mikalev E, Freedman JE.
Nat Commun. 2016 Apr 26;7:11106. "Diverse human extracellular RNAs are widely detected in human plasma." Freedman JE, Gerstein M, Mick E, Rozowsky J, Levy D, Kitchen R, Das S, Shah R, Danielson K, Beaulieu L, Navarro FC, Wang Y, Galeev TR, Holman A, Kwong RY, Murthy V, Tanriverdi SE, Koupenova-Zamor M, Mikhalev E, Tanriverdi K.
Anal Biochem. 2016 May 15;501:66-74. "Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative polymerase chain reaction." Tanriverdi K, Kucukural A, Mikhalev E, Tanriverdi SE, Lee R, Ambros VR, Freedman JE.
Nat Commun. 2015 Mar 20;6:6601. "Genome-wide identification of microRNA expression quantitative trait loci." Huan T, Rong J, Liu C, Zhang X, Tanriverdi K, Joehanes R, Chen BH, Murabito JM, Yao C, Courchesne P, Munson PJ, O'Donnell CJ, Cox N, Johnson AD, Larson MG, Levy D, Freedman JE.
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):1011-21. "Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses." Huan T, Rong J, Tanriverdi K, Meng Q, Bhattacharya A, McManus DD, Joehanes R, Assimes TL, McPherson R, Samani NJ, Erdmann J, Schunkert H, Courchesne P, Munson PJ, Johnson AD, O'Donnell CJ, Zhang B, Larson MG, Freedman JE, Levy D, Yang X.
Arterioscler Thromb Vasc Biol. 2015 Apr;35(4):1030-7. "Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors." Koupenova M, Mick E, Mikhalev E, Benjamin EJ, Tanriverdi K, Freedman JE.
Heart Rhythm. 2015 Jan;12(1):3-10. "Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study)." McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF Jr, Donahue JK, Benjamin EJ, Freedman JE.
Heart Rhythm. 2014 Apr;11(4):663-9. "Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study." McManus DD, Lin H, Tanriverdi K, Quercio M, Yin X, Larson MG, Ellinor PT, Levy D, Freedman JE, Benjamin EJ.
Fam Med Med Sci Res. 2013 Oct 1;2(2):108. "Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction." Ward JA, Esa N, Pidikiti R, Freedman JE, Keaney JF, Tanriverdi K, Vitseva O, Ambros V, Lee R, McManus DD.
Hum Mol Genet. 2014 Feb 1;23(3):782-95. "Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes." Zhang X, Johnson AD, Hendricks AE, Hwang SJ, Tanriverdi K, Ganesh SK, Smith NL, Peyser PA, Freedman JE, O'Donnell CJ.
Arterioscler Thromb Vasc Biol. 2013 Nov;33(11):2666-73. "Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk." McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF Jr, Benjamin EJ, Freedman JE.
Arterioscler Thromb Vasc Biol. 2013 Jun;33(6):1418-26. "Gene expression signatures of coronary heart disease." Joehanes R, Ying S, Huan T, Johnson AD, Raghavachari N, Wang R, Liu P, Woodhouse KA, Sen SK, Tanriverdi K, Courchesne P, Freedman JE, O'Donnell CJ, Levy D, Munson PJ.
J Am Coll Cardiol. 2011 Jul 12;58(3):232-7. "Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity." Farb MG, Bigornia S, Mott M, Tanriverdi K, Morin KM, Freedman JE, Joseph L, Hess DT, Apovian CM, Vita JA, Gokce N.
J Rheumatol. 2011 Jun;38(6):1048-54. "Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis." Tomasson G, Lavalley M, Tanriverdi K, Finkielman JD, Davis JC Jr, Hoffman GS, McCune WJ, St Clair EW, Specks U, Spiera R, Stone JH, Freedman JE, Merkel PA; Wegener's Granulomatosis Etanercept Trial (WGET) Research Group.
Circulation. 2010 Jul 13;122(2):119-29. "Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study." Freedman JE, Larson MG, Tanriverdi K, O'Donnell CJ, Morin K, Hakanson AS, Vasan RS, Johnson AD, Iafrati MD, Benjamin EJ.