Funding and Awards

The following is a brief summary of Center for Asthma Research investigator funding focused on asthma and allergic diseases.

In addition to a robustly funded translational program, our trainees and junior investigators have been highly successful with four NIH mentored career investigator K awards, two T32 awards, and four OIF awards.

Our program alumni are faculty and leaders across the United States.

R01/R21 Awards

Topic	PI(s)	Funding Source	Type	Description
PRECISE	Castro, Bacharier	NIH	R01	Precision biologic interventions for severe exacerbation prone asthma clinical center
Stress, Antioxidants, and Asthma	Carroll, Wright, Moore	NIH	R01	Maternal traumatic stress, oxidative stress, antioxidant exposures, and child asthma and lung function
RSV and Respiratory Morbidity in Children w/ Down-Syndrome	Wu, Dupont	NIH	R01	The effectiveness of RSV immunoprophylaxis on the short- and long-term respiratory morbidity in children with Down syndrome
T-Cell Metabolism in Asthma	Newcomb, Rathmell	NIH	R01	Test candidate targets to suppress glutamine metabolism in animal models and patient samples
Androgen Signaling in Allergic Airway Inflammation	Newcomb	NIH	R01	Develop asthma therapeutics for diseases w/increased IL-33
GLP-1R Signaling in Allergic Inflammation	Peebles, Niswender	NIH	R01	GLP-1R signaling as a negative regulator of early innate and adaptive immune responses.
LMA Use in Asthma and Allergic Rhinitis and Influenza Risk	Hartert, Braciale	NIH	R01	A study of leukotriene modifying agents in the prevention of excess morbidity and mortality from influenza
PGI2 Augments Treg Function	Peebles	NIH	R01	A study to understand the host's inability to signal through the prostaglandin (PG)I2 receptor impedes immune tolerance and demonstrate that treatment with PGI2 analogs promotes tolerance
Azithromycin After Severe RSV Brochiolitis	Beigelman, Bacharier, Srinivasan	NIH	R01	Randomized controlled trial of azithromycin to prevent recurrent wheezing following severe RSV bronchiolitis
E-cigarette Use During Pregnancy	Wu	NIH	R21	Impact of e-cigarette use during pregnancy on newborn metabolic profile and perinatal health outcomes
Elucidating the role of nasopharyngeal microbiome in Respiratory Syncytial Virus associated diseases in children	Das, Hartert	NIH	R21	A study capitalizing upon an in-place birth cohort specifically designed to understand the role of viral infection and the microbiome on childhood respiratory disease morbidity
The airway fungome and asthma	Rosas-Salazar, Das, Hartert	NIH	R21	A study capitalizing upon an in-place birth cohort to delineate the role of the fungome in childhood asthma development
Establishing critical time windows of infant RSV infection in the causal relationship of RSV and childhood asthma	Hartert, Wu	NHLBI	R01	Study defining key timing of RSV exposure and its causal role in childhood asthma onset.
GLP-1R agonist immune targets in lean and obesity-associated asthma	Cahill	NIAID	R01	Examination of GLP-1 receptor agonists' immune effects in different asthma subtypes.
Mechanisms by which Glp-1 and Gip receptor signaling enhance airway epithelial barrier function	Cahill	NIAID	R21	Research on GLP-1/GIP signaling's role in strengthening airway barriers.
Androgens inhibit IL-33 production and airway inflammation	Newcomb	NHLBI	R01	Study of androgen effects on reducing IL-33-driven inflammation in airways.
Effect of infant antibiotics on the development of the early-life airway and gut microbiome and risk of childhood asthma	Rosas-Salazar	NHLBI	R01	Analysis of antibiotic impacts on microbiomes and subsequent asthma risk.

Center Program Awards

Topic	PI(s)	Funding Source	Type	Description
TEAM: Treating Exacerbations of Asthma with Montelukast	Arnold, Bacharier	NIH	R34	Adaptive, double-masked RCT in children with moderate or severe asthma exacerbations comparing standard treatment plus high-dose oral montelukast or placebo, with 3 escalating mg/kg montelukast dose-levels determined by pharmacokinetic-guided dose modeling.
Identifying asthma phenotypes and endotypes to develop targeted treatment and prevention strategies for childhood asthma	Hartert and Bacharier	NIH	UG3	Continuation of INSPIRE cohort under collaboration with the Environmental Influences on Child Health Outcomes (ECHO) program.
Delineating the severity-dependent and age-dependent effects of RSV infection on asthma risk	Hartert and Osmundson	NIH	UG3	Continuation of CANOE cohort under collaboration with the Environmental Influences on Child Health Outcomes (ECHO) program
RSV and Asthma: Viral and Host Factors in Asthma Development	Peebles, Hartert	NIH	U19	The proposed investigations of host-viral interactions leading to childhood asthma development uses the model of respiratory syncytial virus (RSV) infections in early life to understand the development of chronic respiratory morbidity and test intervention strategies to prevent severe RSV infection and asthma Public study website
RSV and Asthma: Defining Host and Exposure Variation on Disease Development	Hartert	NIH	U19	The overarching objectives are: 1) To determine whether the age of first infant RSV infection is associated with risk of subsequent incident recurrent wheeze and asthma 2) To delineate the longitudinal effects of RSV on airway epithelial cell differentiation and metabolism throughout infancy and childhood 3) To evaluate host gene infant RSV infection interactions and RSV-dependent NAEC DNAm longitudinally to identify changes and temporal stability of RSV-dependent DNAm marks and their association with recurrent wheeze and asthma.
Mechanisms of Dietary Citrulline in RSV Infection Severity	Peebles	NIH	U19	To determine RSV-induced type 2 immune responses and whether they are inhibited by dietary citrulline supplementation during gestation and early life in a murine model of RSV infection
The Clinical Ascertainment, Biospecimen Acquisition, Data Management and Analysis Research Core	Hartert	NIH	U19	This Core facilitates and oversees longitudinal follow-up of the established INSPIRE cohort and the recruitment, enrollment, and longitudinal follow-up of the new CANOE-VU cohort. It supports the collection and management of key biospecimens and data from both cohorts for U19 Projects 1 and 2
RSV and Asthma: Data Management and Analysis Research Core	Gebretsadik	NIH	U19	This Core provides essential services in data management, analytic support, and conducting and overseeing biostatistical analyses for the U19 Projects. This Core has an excellent record of managing and analyzing complex human and animal sample data, employs state-of-the-art biostatistical methodologies and rigorous statistical analyses
Human Epidemiology and Response to SARS-CoV-2 (HEROS) study	Hartert, Brunwasser, Gebretsadik, Dupont	NIH	U19	12-city study of incidence, transmission and nasal gene expression patterns of SARS-CoV-2 in households with children and among individuals with asthma and atopic conditions Public study website
ECHO-CREW Asthma Consortium	Gern, Hartert	NIH	UH3	Children's Respiratory and Environmental Workgroup (CREW) consortium for the INSPIRE and CANOE cohorts Public study website
GATA-3	Cahill, Bernard, Dupont, Peebles, Wu	NIH	U01	Randomized controlled trial of glucagon-like peptide-1 receptor agonist treatment in adult, obesity-related, symptomatic asthma
Merit Award	Peebles	VA	I01	PGI2 inhibition of pulmonary innate allergic immune responses
Developmental Impact of NICU Exposures (DINE)	Aschner, Strousstrup, Teitelbaum, Bacharier	NIH	UH3	Multi-site cohort will clarify the role of potentially avoidable NICU-based phthalate exposure on high-prevelance clinical outcomes
PATHWAYS	Karr, Bush, Lewinn, Mason, Sathyanarayana, Moore	NIH	UH3	An integrated model of chemical and social exposures, biological mechanisms, and sex-specific effects on neurodevelopment and respiratory outcomes
Systems Biology of Early Atopy (SUNBEAM)	Bacharier, Hartert	NIH		A study to identify prenatal and early childhood markers of high risk for food allergy and atopic dermatitis, or eczema, as well as biological pathways that lead to these conditions
Viral and Host Determinants of Infant and Childhood Allergy and Asthma	Hartert, Peebles	NIAID	U19	Multi-project center investigating viral and host factors in early-life allergy and asthma development.
ECHO Renewal for the INSPIRE Study Cohort	Hartert, Bacharier	OD	UH3	Renewal of INSPIRE cohort integrating with ECHO program for long-term childhood health outcomes.
RSV-induced type 2 immune responses are inhibited by dietary citrulline supplementation during gestation and early life	Peebles	NIAID	U19	Testing citrulline supplementation to block RSV-driven type 2 immunity.

Career Development Awards

Topic	PI (sponsor)	Funding Source	Type	Description
MOTHER SEED	Rosas-Salazar, Hartert	NIH	K23	Early-life nasal colonization with Lactobacillus, development of local immune response and later onset of recurrent wheeze, childhood asthma, and allergic rhinitis
Multiomics Endotypes of Allergy and Asthma	Turi, Hartert	NIH	K01	Identification of early metabolomic and immune endotypes of allergy and asthma: an integrated multiomics approach
Molecular Pathways in Childhood Asthma	Snyder, Hartert	NIH	KL2	Identifying molecular pathways in childhood asthma pathogenesis by integrating newborn metabolic profiles and GWAS data
PGI2 Restrains Immunopathogenesis in Hypertension	Norlander, Peebles	NIH	K99/00	Determine mechanisms by which PGI2 restrains immune cell function in hypertension
Methods for Platelet Assessment in Asthma	Cahill, Peebles	NIH	OIF U19	Development of a method to assess the role and function of platelets in asthma control
New analytic approach for inferring DNA methylation regions in high-dimensional longitudinal DNAm data	McKennan, Hartert	NIH	OIF U19	New analytic approach for inferring DNA methylation regions in high-dimensional longitudinal DNAm data
Airway microbiome in childhood asthma development	Rosas-Salazar, Hartert	NIH	OIF U19	Study of the association of the nasal airway microbiome in the development of recurrent wheeze and asthma
Newborn screening metabolites and childhood disease	Snyder, Hartert	NIH	OIF UH3	ECHO-wide study of the association of newborn metabolites with common childhood diseases
Pediatric Cardiorespiratory Research Training Program: Childhood origins of diseases across the lifespan	Bacharier, Kannankeril	NHLBI	T32	Training program on early-life origins of cardiorespiratory diseases.
Interdisciplinary Training Program in Lung Research	Peebles	NHLBI	T32	Training grant for lung disease research across disciplines.
The association of placental gene expression and newborn metabolic profiles in understanding childhood asthma pathogenesis	Snyder	NHLBI	K01	Career development award linking placental gene expression, newborn metabolism, and asthma origins.

Other Awards

Topic	PI(s)	Funding Source	Type	Description
Audi Cy Pres Award	Hartert and Vandenbergh			Pre-, peri-, and postnatal fossil fuel environmental exposures and association with adverse maternal and child health outcomes in urban and rural Tennessee and assessing the health impact of transition to fossil fuel vehicles.
Meta-analytic Techniques: RSV and Asthma	Hartert, Brunwasser, Ortiz	WHO, BMGF	N/A	Methodological considerations for studies to measure the association between RSV LRTI and wheeze/asthma
Gene by RSV Interaction and Asthma	Hartert	SNFS	UG3	The contribution of human genetic variation and RSV infection to asthma susceptibility
American Lung Association (ALA)	Bacharier, Cahill	ALA	U01	A Lung Health Cohort study to understand ideal respiratory health and the key risk factors and biomarkers associated with impaired lung health
PGI2 regulation of CD4+ Th2 metabolism in allergic airway inflammation	Peebles	VA	I01	Exploration of prostacyclin (PGI2) effects on CD4+ Th2 cell metabolism in allergic airway inflammation.

Professional organizations

American Academy of Allergy, Asthma and Immunology (AAAAI)
American Academy of Pediatrics (AAP)
American Association for the Advancement of Science (AAAS)
American College of Allergy, Asthma and Immunology (ACAAI)
American College of Obstetricians and Gynecologists (ACOG)
American Epidemiological Society
American Medical Association (AMA)
American Physician Scientists Association
American Public Health Association (APHA)
American Society for Clinical Investigation (ASCI)
American Society of Human Genetics (ASHG)
American Statistical Association (ASA)
American Thoracic Society (ATS)
Association of American Physicians (AAP)
Association for Clinical and Translational Science (ACTS)
Collegium Internationale Allergologicum (CIA)
International Biometrics Society (IBS)
Metabolomics Society
Pediatric Academic Societies
Postpartum Support International (PSI)
Society for Epidemiologic Research (SER)
Society for Prevention Research (SPR)
Society for Maternal-Fetal Medicine (SMFM)
The International Marcé Society