Project Overview
The Center for Asthma Research is recognized at national and international levels for its research and clinical programs.
Drawing upon a multi-disciplinary approach, CAR faculty have the opportunity to actively develop unique research resources from basic sciences to epidemiology.
One major emphasis lies on training the next generation of asthma/allergic disease investigators and clinicians. As such, the Center currently has four K-awardees, two T32s, three OIF awards, and one K-award transitioned to independent funding.
Sponsored Research
2021 Direct Funding
(7) U-Awards, (9) R01, (1) R21, (7) K/OIF, (1) I01, (2) Other
Scope of Activities
We have current funded research programs in basic science, translational, clinical research, population-based research, and epidemiology. These programs are highly integrated and provide many opportunities for research trainees.
Basic Science
- Prostacyclin regulation of allergic disease
- Hormonal regulation and sex differences in allergic disease
- Amino acid regulation of RSV infection
- T-cell metabolism in allergic airway inflammation
Translational
- Airway epithelial development in childhood asthma
- Airway and systemic metabolism in childhood asthma development
- Role of platelets in AERD
- Leukotriene modification in influenza entry and replication in AECs
- Airway microbiome and asthma
Clinical
- RCT of GLP1RA in obese asthma
- Environmental determinants of asthma and allergic disease development
- Role of respiratory viruses in asthma inception
- Airway and systemic metabolism in asthma development
- Systems approach to disease endotyping
Population
- Effectiveness of RSV immunoprophylaxis in selected populations
- Impact of LMAs on pandemic influenza
- Environmental influences on respiratory infections and asthma
- Effect of e-cigarette use during pregnancy
- Role of allergic disease in COVID risk and transmission
Sponsors
Academic Collaborations
- Albert Einstein College of Medicine
- Boston’s Children’s Hospital
- Brigham and Women’s Hospital (Harvard)
- Children’s National Medical Center
- Cincinnati Children’s Hospital
- Colorado Public School of Health
- École Polytechnique Fédérale de Lausanne (CH)
- Emory University
- Erasmus University Medical Center (NL)
- Harvard University
- Henry Ford Health System
- Johns Hopkins University
- Kaiser Permanente, Northern California
- Kansas University Medical Center
- Louisiana State University
- Manchester Metropolitan University
- Marshfield Clinic
- Massachusetts General Hospital
- Mayo Clinic
- Michigan State University
- Mt. Sinai Medical Center
- National Jewish Health
- Northwestern University
- Oregon Health and Science University
- Radboud Universiteit Nijmegen (NL)
- Rowan University
- University of Arizona
- University of California, Berkeley
- University of California, San Francisco
- University of Chicago
- University of Colorado
- University of Copenhagen, DK
- University of Indiana
- University of Iowa
- University of Lausanne (UNIL)
- University of Maryland
- Universitair Medisch Centrum Utrecht (NL)
- University of North Carolina
- University of Pittsburgh
- University of Rochester
- University of Washington (Seattle)
- University of Wisconsin-Madison
- Universität Zürich (CH)
- Vanderbilt University
- Washington University (St. Louis)
