Current Projects

The following is a brief summary of current Center for Asthma Research investigator 2022 funding focused on asthma and allergic diseases.

In addition to a robustly funded translational program, our trainees and junior investigators have been highly successful with four NIH mentored career investigator K awards, two T32 awards, and four OIF awards.

Our program alumni are faculty and leaders across the United States.

TopicPI(s)Funding SourceTypeDescription

Identifying asthma phenotypes and endotypes to develop targeted treatment and prevention strategies for childhood asthma

Hartert and BacharierNIHUG3Continuation of INSPIRE cohort under collaboration with the Environmental Influences on Child Health Outcomes (ECHO) program.
Delineating the severity-dependent and age-dependent effects of RSV infection on asthma riskHartert and OsmundsonNIHUG3Continuation of CANOE cohort under collaboration with the Environmental Influences on Child Health Outcomes (ECHO) program
RSV and Asthma: Viral and Host Factors in Asthma Development Peebles, Hartert NIHU19

The proposed investigations of host-viral interactions leading to childhood asthma development uses the model of respiratory syncytial virus (RSV) infections in early life to understand the development of chronic respiratory morbidity and test intervention strategies to prevent severe RSV infection and asthma

Public study website

RSV and Asthma: Defining Host and Exposure Variation on Disease DevelopmentHartert  NIHU19

The overarching objectives are: 

1) To determine whether the age of first infant RSV infection is associated with risk of subsequent incident recurrent wheeze and asthma

2) To delineate the longitudinal effects of RSV on airway epithelial cell differentiation and metabolism throughout infancy and childhood

3) To evaluate host gene infant RSV infection interactions and RSV-dependent NAEC DNAm longitudinally to identify changes and temporal stability of RSV-dependent DNAm marks and their association with recurrent wheeze and asthma.

Mechanisms of Dietary Citrulline in RSV Infection SeverityPeebles    NIHU19

To determine RSV-induced type 2 immune responses and whether they are inhibited by dietary citrulline supplementation during gestation and early life in a murine model of RSV infection

The Clinical Ascertainment, Biospecimen Acquisition, Data Management and Analysis Research Core


This Core facilitates and oversees longitudinal follow-up of the established INSPIRE cohort and the recruitment, enrollment, and longitudinal follow-up of the new CANOE-VU cohort. It supports the collection and management of key biospecimens and data from both cohorts for U19 Projects 1 and 2

RSV and Asthma: Data Management and Analysis Research CoreGebretsadik NIHU19

This Core provides essential services in data management, analytic support, and conducting and overseeing biostatistical analyses for the U19 Projects.

This Core has an excellent record of managing and analyzing complex human and animal sample data, employs state-of-the-art biostatistical methodologies and rigorous statistical analyses

Human Epidemiology and Response to SARS-CoV-2 (HEROS) studyHartert, Brunwasser, Gebretsadik, Dupont NIHU19

12-city study of incidence, transmission and nasal gene expression patterns of SARS-CoV-2 in households with children and among individuals with asthma and atopic conditions

Public study website

ECHO-CREW Asthma ConsortiumGern, Hartert  NIHUH3

Children's Respiratory and Environmental Workgroup (CREW) consortium for the INSPIRE and CANOE cohorts

Public study website

GATA-3Cahill, Bernard, Dupont, Peebles, WuNIHU01

Randomized controlled trial of glucagon-like peptide-1 receptor agonist treatment in adult, obesity-related, symptomatic asthma

Merit AwardPeeblesVAI01

PGI2 inhibition of pulmonary innate allergic immune responses

Developmental Impact of NICU Exposures (DINE)Aschner, Strousstrup, Teitelbaum, Bacharier NIHUH3

Multi-site cohort will clarify the role of potentially avoidable NICU-based phthalate exposure on high-prevelance clinical outcomes

PATHWAYSKarr, Bush, Lewinn, Mason, Sathyanarayana, Moore NIHUH3

An integrated model of chemical and social exposures, biological mechanisms, and sex-specific effects on neurodevelopment and respiratory outcomes

Systems Biology of Early Atopy (SUNBEAM)

Bacharier, Hartert


A study to identify prenatal and early childhood markers of high risk for food allergy and atopic dermatitis, or eczema, as well as biological pathways that lead to these conditions

Professional organizations

  • American Academy of Allergy, Asthma and Immunology (AAAI)
  • American Academy of Pediatrics (AAP)
  • American Association for the Advancement of Science (AAAS)
  • American College of Allergy, Asthma and Immunology (ACAAI)
  • American College of Obstetricians and Gynecologists (ACOG)
  • American Medical Association (AMA)
  • American Public Health Association (APHA)
  • American Society for Clinical Investigation (ASCI)
  • American Society of Human Genetics (ASHG)
  • American Statistical Association (ASA)
  • American Thoracic Society (ATS)
  • Association of American Physicians (AAP)
  • Association for Clinical and Translational Science (ACTS)
  • Collegium Internationale Allergologicum (CIA)
  • International Biometrics Society (IBS)
  • Metabolomics Society    
  • Pediatric Academic Societies
  • Postpartum Support International (PSI)
  • Society for Epidemiologic Research (SER)
  • Society for Prevention Research (SPR)
  • Society for Maternal-Fetal Medicine (SMFM)
  • The International Marcé Society